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Rheb fills a GAP between TSC and TOR.
Manning BD, Cantley LC. Manning BD, et al. Trends Biochem Sci. 2003 Nov;28(11):573-6. doi: 10.1016/j.tibs.2003.09.003. Trends Biochem Sci. 2003. PMID: 14607085 Review.
The LKB1 tumor suppressor negatively regulates mTOR signaling.
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. Shaw RJ, et al. Among authors: manning bd. Cancer Cell. 2004 Jul;6(1):91-9. doi: 10.1016/j.ccr.2004.06.007. Cancer Cell. 2004. PMID: 15261145
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