Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 2
1990 2
1991 1
1993 1
1995 1
1996 3
1997 1
1998 1
1999 1
2000 2
2002 1
2003 1
2004 1
2005 1
2006 1
2009 2
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

22 results

Results by year

Filters applied: . Clear all
Page 1
Mannostatin A, a new glycoprotein-processing inhibitor.
Tropea JE, Kaushal GP, Pastuszak I, Mitchell M, Aoyagi T, Molyneux RJ, Elbein AD. Tropea JE, et al. Biochemistry. 1990 Oct 30;29(43):10062-9. doi: 10.1021/bi00495a008. Biochemistry. 1990. PMID: 2271638
However, it was virtually inactive toward mannosidase I. The N-acetylated derivative of mannostatin A had no inhibitory activity. In cell culture studies, mannostatin A also proved to be a potent inhibitor of glycoprotein processing. ...This observation is in keepin …
However, it was virtually inactive toward mannosidase I. The N-acetylated derivative of mannostatin A had no inhibitory activity. In …
Cyclopentanes from N-amino-glyconolactams. A synthesis of mannostatin A.
Hu G, Zimmermann M, Ramana CV, Vasella A. Hu G, et al. Chem Commun (Camb). 2003 Apr 21;(8):952-3. doi: 10.1039/b301213a. Chem Commun (Camb). 2003. PMID: 12744315
Oxidation of a N-amino-ribonolactam with lead tetraacetate yields two cyclopentanes; the major one was transformed into the alpha-mannosidase inhibitor mannostatin A....
Oxidation of a N-amino-ribonolactam with lead tetraacetate yields two cyclopentanes; the major one was transformed into the alpha-mannosidas …
Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies.
Li B, Kawatkar SP, George S, Strachan H, Woods RJ, Siriwardena A, Moremen KW, Boons GJ. Li B, et al. Chembiochem. 2004 Sep 6;5(9):1220-7. doi: 10.1002/cbic.200300842. Chembiochem. 2004. PMID: 15368573
Mannostatin and aminocyclopentitetrol analogues with various substitutions at the amino function were synthesized. These compounds were tested as inhibitors of human Golgi and lysosomal alpha-mannosidases. Modification of the amine of mannostatin had only marginal e …
Mannostatin and aminocyclopentitetrol analogues with various substitutions at the amino function were synthesized. These compounds we …
The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A.
Kuntz DA, Zhong W, Guo J, Rose DR, Boons GJ. Kuntz DA, et al. Chembiochem. 2009 Jan 26;10(2):268-77. doi: 10.1002/cbic.200800538. Chembiochem. 2009. PMID: 19101978 Free PMC article.
Mannostatin A is a potent inhibitor of the mannose-trimming enzyme, Golgi alpha-mannosidase II (GMII), which acts late in the N-glycan processing pathway. ...Here, we report on the synthesis of new Mannostatin derivatives and analyze their binding in the active site …
Mannostatin A is a potent inhibitor of the mannose-trimming enzyme, Golgi alpha-mannosidase II (GMII), which acts late in the N-glyca …
Pd asymmetric allylic alkylation (AAA). A powerful synthetic tool.
Trost BM. Trost BM. Chem Pharm Bull (Tokyo). 2002 Jan;50(1):1-14. doi: 10.1248/cpb.50.1. Chem Pharm Bull (Tokyo). 2002. PMID: 11824567 Free article. Review.
These methods have already provided practical strategies towards numerous biological targets--some of which are adenosine and its enantiomer, aflatoxin B, aristeromycin, calanolide A and B, carbovir, cyclophellitol, ethambutol, galanthamine, mannostatin, neplanocin, phylla …
These methods have already provided practical strategies towards numerous biological targets--some of which are adenosine and its enantiomer …
Structural basis of the inhibition of Golgi alpha-mannosidase II by mannostatin A and the role of the thiomethyl moiety in ligand-protein interactions.
Kawatkar SP, Kuntz DA, Woods RJ, Rose DR, Boons GJ. Kawatkar SP, et al. J Am Chem Soc. 2006 Jun 28;128(25):8310-9. doi: 10.1021/ja061216p. J Am Chem Soc. 2006. PMID: 16787095 Free PMC article.
In the bound state, mannostatin A adopts a 2T1 twist envelope conformation, which is not significantly populated in solution. Possible conformations of the mannosyl oxacarbenium ion and an enzyme-linked intermediate have been compared to the conformation of mannostatin …
In the bound state, mannostatin A adopts a 2T1 twist envelope conformation, which is not significantly populated in solution. Possibl …
Inhibition of experimental metastasis by enzyme inhibitors from microorganisms and plants.
Umezawa K. Umezawa K. Adv Enzyme Regul. 1996;36:267-81. doi: 10.1016/0065-2571(95)00014-3. Adv Enzyme Regul. 1996. PMID: 8869751 Review.
Alpha-glucosidase inhibitors such as epi-CPL and baicalein inhibited in vitro invasion and in vivo metastasis of mouse melanoma cells. A mannosidase inhibitor, mannostatin A, also inhibited in vitro invasion of mouse melanoma cells. Oncogene function inhibitors induce norm …
Alpha-glucosidase inhibitors such as epi-CPL and baicalein inhibited in vitro invasion and in vivo metastasis of mouse melanoma cells. A man …
Inhibition of tumor cell invasion in the Boyden chamber assay by a mannosidase inhibitor, mannostatin A.
Ochi Y, Atsumi S, Aoyagi T, Umezawa K. Ochi Y, et al. Anticancer Res. 1993 Sep-Oct;13(5A):1421-4. Anticancer Res. 1993. PMID: 8239514
Addition of mannostatin A to the cultured B16/F10 or K-ras-NIH3T3 cells inhibited cellular alpha-mannoside activity specifically. Mannostatin A-treated B16/F10 cells also showed decreased metastatic activity in vivo in C57Bl/6 mice....
Addition of mannostatin A to the cultured B16/F10 or K-ras-NIH3T3 cells inhibited cellular alpha-mannoside activity specifically. …
Synthesis and biological evaluation of alpha-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A.
Ogawa S, Morikawa T. Ogawa S, et al. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1499-504. doi: 10.1016/s0960-894x(99)00224-3. Bioorg Med Chem Lett. 1999. PMID: 10386924
Three deoxy derivatives of alpha-mannosidase inhibitor mannostatin A have been synthesized and their inhibitors activity for Jack beans alpha-mannosidase evaluated in order to elucidate roles of each hydroxyl groups of the inhibitor The 1- and 2-deoxy derivatives have pres …
Three deoxy derivatives of alpha-mannosidase inhibitor mannostatin A have been synthesized and their inhibitors activity for Jack bea …
22 results