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L-Carnitine and acetyl-L-carnitine in the treatment of complications associated with HIV infection and antiretroviral therapy.
Ilias I, Manoli I, Blackman MR, Gold PW, Alesci S. Ilias I, et al. Among authors: manoli i. Mitochondrion. 2004 Jul;4(2-3):163-8. doi: 10.1016/j.mito.2004.05.012. Mitochondrion. 2004. PMID: 16120381
Indeed, oral, i.v., or i.m. administration of large doses of LC and/or ALC to HIV positive subjects untreated/treated with HAART was shown to: (1) increase the number of CD4 cells and reduce lymphocyte apoptosis; (2) improve symptoms of polyneuropathy; (3) prevent c …
Indeed, oral, i.v., or i.m. administration of large doses of LC and/or ALC to HIV positive subjects untreated/treated with HAA …
Modulatory effects of L-carnitine on glucocorticoid receptor activity.
Manoli I, De Martino MU, Kino T, Alesci S. Manoli I, et al. Ann N Y Acad Sci. 2004 Nov;1033:147-57. doi: 10.1196/annals.1320.014. Ann N Y Acad Sci. 2004. PMID: 15591012 Review.
Development of a human mitochondria-focused cDNA microarray (hMitChip) and validation in skeletal muscle cells: implications for pharmaco- and mitogenomics.
Alesci S, Manoli I, Michopoulos VJ, Brouwers FM, Le H, Gold PW, Blackman MR, Rennert OM, Su YA, Chrousos GP. Alesci S, et al. Among authors: manoli i. Pharmacogenomics J. 2006 Sep-Oct;6(5):333-42. doi: 10.1038/sj.tpj.6500377. Epub 2006 Mar 14. Pharmacogenomics J. 2006. PMID: 16534508
Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system.
Kino T, Souvatzoglou E, Charmandari E, Ichijo T, Driggers P, Mayers C, Alatsatianos A, Manoli I, Westphal H, Chrousos GP, Segars JH. Kino T, et al. Among authors: manoli i. J Biol Chem. 2006 Apr 7;281(14):9118-26. doi: 10.1074/jbc.M509339200. Epub 2006 Feb 8. J Biol Chem. 2006. PMID: 16469733 Free PMC article.
Third-generation human mitochondria-focused cDNA microarray and its bioinformatic tools for analysis of gene expression.
Bai X, Wu J, Zhang Q, Alesci S, Manoli I, Blackman MR, Chrousos GP, Goldstein AL, Rennert OM, Su YA. Bai X, et al. Among authors: manoli i. Biotechniques. 2007 Mar;42(3):365-75. doi: 10.2144/000112388. Biotechniques. 2007. PMID: 17390543
Mitochondria as key components of the stress response.
Manoli I, Alesci S, Blackman MR, Su YA, Rennert OM, Chrousos GP. Manoli I, et al. Trends Endocrinol Metab. 2007 Jul;18(5):190-8. doi: 10.1016/j.tem.2007.04.004. Epub 2007 May 17. Trends Endocrinol Metab. 2007. PMID: 17500006 Review.
Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity.
Kino T, Manoli I, Kelkar S, Wang Y, Su YA, Chrousos GP. Kino T, et al. Among authors: manoli i. Biochem Biophys Res Commun. 2009 Apr 17;381(4):671-5. doi: 10.1016/j.bbrc.2009.02.110. Epub 2009 Feb 25. Biochem Biophys Res Commun. 2009. PMID: 19248771 Free PMC article.
Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine.
Galeano B, Klootwijk R, Manoli I, Sun M, Ciccone C, Darvish D, Starost MF, Zerfas PM, Hoffmann VJ, Hoogstraten-Miller S, Krasnewich DM, Gahl WA, Huizing M. Galeano B, et al. Among authors: manoli i. J Clin Invest. 2007 Jun;117(6):1585-94. doi: 10.1172/JCI30954. J Clin Invest. 2007. PMID: 17549255 Free PMC article.
Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia.
Manoli I, Sysol JR, Li L, Houillier P, Garone C, Wang C, Zerfas PM, Cusmano-Ozog K, Young S, Trivedi NS, Cheng J, Sloan JL, Chandler RJ, Abu-Asab M, Tsokos M, Elkahloun AG, Rosen S, Enns GM, Berry GT, Hoffmann V, DiMauro S, Schnermann J, Venditti CP. Manoli I, et al. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13552-7. doi: 10.1073/pnas.1302764110. Epub 2013 Jul 29. Proc Natl Acad Sci U S A. 2013. PMID: 23898205 Free PMC article. Clinical Trial.
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