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A brain serine/threonine protein kinase activated by Cdc42 and Rac1.
Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. Manser E, et al. Nature. 1994 Jan 6;367(6458):40-6. doi: 10.1038/367040a0. Nature. 1994. PMID: 8107774
Differential distribution of alpha and beta isoforms of p21-activated kinase in the monkey cerebral neocortex and hippocampus.
Ong WY, Wang XS, Manser E. Ong WY, et al. Among authors: manser e. Exp Brain Res. 2002 May;144(2):189-99. doi: 10.1007/s00221-002-1016-x. Epub 2002 Apr 10. Exp Brain Res. 2002. PMID: 12012157
p21-activated kinase PAK phosphorylates desmin at sites different from those for Rho-associated kinase.
Ohtakara K, Inada H, Goto H, Taki W, Manser E, Lim L, Izawa I, Inagaki M. Ohtakara K, et al. Among authors: manser e. Biochem Biophys Res Commun. 2000 Jun 16;272(3):712-6. doi: 10.1006/bbrc.2000.2854. Biochem Biophys Res Commun. 2000. PMID: 10860820
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.
Chong C, Tan L, Lim L, Manser E. Chong C, et al. Among authors: manser e. J Biol Chem. 2001 May 18;276(20):17347-53. doi: 10.1074/jbc.M009316200. Epub 2001 Feb 22. J Biol Chem. 2001. PMID: 11278486
Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.
Mott HR, Owen D, Nietlispach D, Lowe PN, Manser E, Lim L, Laue ED. Mott HR, et al. Among authors: manser e. Nature. 1999 May 27;399(6734):384-8. doi: 10.1038/20732. Nature. 1999. PMID: 10360579
cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha.
Dong JM, Leung T, Manser E, Lim L. Dong JM, et al. Among authors: manser e. J Biol Chem. 1998 Aug 28;273(35):22554-62. doi: 10.1074/jbc.273.35.22554. J Biol Chem. 1998. PMID: 9712882
Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.
Cvrcková F, De Virgilio C, Manser E, Pringle JR, Nasmyth K. Cvrcková F, et al. Among authors: manser e. Genes Dev. 1995 Aug 1;9(15):1817-30. doi: 10.1101/gad.9.15.1817. Genes Dev. 1995. PMID: 7649470
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
Eisenmann KM, McCarthy JB, Simpson MA, Keely PJ, Guan JL, Tachibana K, Lim L, Manser E, Furcht LT, Iida J. Eisenmann KM, et al. Among authors: manser e. Nat Cell Biol. 1999 Dec;1(8):507-13. doi: 10.1038/70302. Nat Cell Biol. 1999. PMID: 10587647
A 68-kDa kinase and NADPH oxidase component p67phox are targets for Cdc42Hs and Rac1 in neutrophils.
Prigmore E, Ahmed S, Best A, Kozma R, Manser E, Segal AW, Lim L. Prigmore E, et al. Among authors: manser e. J Biol Chem. 1995 May 5;270(18):10717-22. doi: 10.1074/jbc.270.18.10717. J Biol Chem. 1995. PMID: 7738010
Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain.
Leung T, How BE, Manser E, Lim L. Leung T, et al. Among authors: manser e. J Biol Chem. 1994 Apr 29;269(17):12888-92. J Biol Chem. 1994. PMID: 8175705
beta-Chimaerin, a 30-kDa GTPase-activating protein (GAP) for the p21 Ras-related Rac, is expressed specifically in late stage spermatocytes (Leung, T., How, B.-E., Manser, E., and Lim, L. (1993) J. Biol. Chem. 268, 3813-3816). ...
beta-Chimaerin, a 30-kDa GTPase-activating protein (GAP) for the p21 Ras-related Rac, is expressed specifically in late stage spermatocytes …
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