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The guanine-exchange factor Ric8a binds to the Ca²⁺ sensor NCS-1 to regulate synapse number and neurotransmitter release.
Romero-Pozuelo J, Dason JS, Mansilla A, Baños-Mateos S, Sardina JL, Chaves-Sanjuán A, Jurado-Gómez J, Santana E, Atwood HL, Hernández-Hernández Á, Sánchez-Barrena MJ, Ferrús A. Romero-Pozuelo J, et al. Among authors: mansilla a. J Cell Sci. 2014 Oct 1;127(Pt 19):4246-59. doi: 10.1242/jcs.152603. Epub 2014 Jul 29. J Cell Sci. 2014. PMID: 25074811 Free article.
Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.
Mansilla A, Chaves-Sanjuan A, Campillo NE, Semelidou O, Martínez-González L, Infantes L, González-Rubio JM, Gil C, Conde S, Skoulakis EM, Ferrús A, Martínez A, Sánchez-Barrena MJ. Mansilla A, et al. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E999-E1008. doi: 10.1073/pnas.1611089114. Epub 2017 Jan 24. Proc Natl Acad Sci U S A. 2017. PMID: 28119500 Free PMC article.
Molecular mechanisms that change synapse number.
Mansilla A, Jordán-Álvarez S, Santana E, Jarabo P, Casas-Tintó S, Ferrús A. Mansilla A, et al. J Neurogenet. 2018 Sep;32(3):155-170. doi: 10.1080/01677063.2018.1506781. Epub 2018 Oct 10. J Neurogenet. 2018. PMID: 30303424 Review.
136 results