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Follicular cells of the thyroid gland require Pax8 gene function.
Mansouri A, Chowdhury K, Gruss P. Mansouri A, et al. Nat Genet. 1998 May;19(1):87-90. doi: 10.1038/ng0598-87. Nat Genet. 1998. PMID: 9590297
Mice lacking the transcription factor Ttf1 lack both cell types and thus are unable to develop a thyroid gland. By analysis of Pax8-/- mice, we demonstrate that Pax8 is required for the formation of the follicular cells in the thyroid. ...
Mice lacking the transcription factor Ttf1 lack both cell types and thus are unable to develop a thyroid gland. By analysis of Pax8-/ …
Differentiation of embryonic stem cells.
Mansouri A, Fukumitsu H, Schindehuette J, Krieglstein K. Mansouri A, et al. Curr Protoc Neurosci. 2009 Apr;Chapter 3:Unit3.6. doi: 10.1002/0471142301.ns0306s47. Curr Protoc Neurosci. 2009. PMID: 19340810
This unit describes a simple procedure that promotes the neuronal differentiation of mouse embryonic stem cells and yields a high proportion of midbrain dopaminergic neurons. ...
This unit describes a simple procedure that promotes the neuronal differentiation of mouse embryonic stem cells and yields a h …
In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells.
Schindehütte J, Fukumitsu H, Collombat P, Griesel G, Brink C, Baier PC, Capecchi MR, Mansouri A. Schindehütte J, et al. Among authors: mansouri a. Stem Cells. 2005;23(1):10-5. doi: 10.1634/stemcells.2004-0163. Stem Cells. 2005. PMID: 15625119
Embryonic stem cells (ES) are pluripotent and may therefore serve as a source for the generation of specific cell types required for future therapies based on cell replacement. The isolation of defined cell populations from a certain lineage or tissue is a pr …
Embryonic stem cells (ES) are pluripotent and may therefore serve as a source for the generation of specific cell types required for …
The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation.
Rabe TI, Griesel G, Blanke S, Kispert A, Leitges M, van der Zwaag B, Burbach JP, Varoqueaux F, Mansouri A. Rabe TI, et al. Among authors: mansouri a. Neural Dev. 2012 Dec 8;7:39. doi: 10.1186/1749-8104-7-39. Neural Dev. 2012. PMID: 23217170 Free PMC article.
The early expression of this transcription factor in the mouse, as well as in the chick midbrain, points to a conserved function of Uncx4.1, but so far a functional analysis in this brain territory is missing. ...CONCLUSION: We conclude that Uncx4.1 is implicated in …
The early expression of this transcription factor in the mouse, as well as in the chick midbrain, points to a conserved function of U …
Ectopic expression of Pax4 in pancreatic δ cells results in β-like cell neogenesis.
Druelle N, Vieira A, Shabro A, Courtney M, Mondin M, Rekima S, Napolitano T, Silvano S, Navarro-Sanz S, Hadzic B, Avolio F, Rassoulzadegan M, Schmid HA, Mansouri A, Collombat P. Druelle N, et al. Among authors: mansouri a. J Cell Biol. 2017 Dec 4;216(12):4299-4311. doi: 10.1083/jcb.201704044. Epub 2017 Oct 12. J Cell Biol. 2017. PMID: 29025873 Free PMC article.
mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium.
Bachmann C, Nguyen H, Rosenbusch J, Pham L, Rabe T, Patwa M, Sokpor G, Seong RH, Ashery-Padan R, Mansouri A, Stoykova A, Staiger JF, Tuoc T. Bachmann C, et al. Among authors: mansouri a. PLoS Genet. 2016 Sep 9;12(9):e1006274. doi: 10.1371/journal.pgen.1006274. eCollection 2016 Sep. PLoS Genet. 2016. PMID: 27611684 Free PMC article.
Neurogenesis is a key developmental event through which neurons are generated from neural stem/progenitor cells. Chromatin remodeling BAF (mSWI/SNF) complexes have been reported to play essential roles in the neurogenesis of the central nervous system. ...Our findings unve …
Neurogenesis is a key developmental event through which neurons are generated from neural stem/progenitor cells. Chromatin remodeling …
Sp6 and Sp8 transcription factors control AER formation and dorsal-ventral patterning in limb development.
Haro E, Delgado I, Junco M, Yamada Y, Mansouri A, Oberg KC, Ros MA. Haro E, et al. Among authors: mansouri a. PLoS Genet. 2014 Aug 28;10(8):e1004468. doi: 10.1371/journal.pgen.1004468. eCollection 2014 Aug. PLoS Genet. 2014. PMID: 25166858 Free PMC article.
Mutants bearing a single functional allele of Sp8 (Sp6-/-;Sp8+/-) exhibit a split-hand/foot malformation phenotype with double dorsal digit tips probably due to an irregular and immature AER that is not maintained in the center of the bud and on the abnormal expansi …
Mutants bearing a single functional allele of Sp8 (Sp6-/-;Sp8+/-) exhibit a split-hand/foot malformation phenotype with double …
Generation of knockout mice expressing a GFP-reporter under the control of the Lmx1a locus.
Griesel G, Krug C, Yurlova L, Diaconu M, Mansouri A. Griesel G, et al. Among authors: mansouri a. Gene Expr Patterns. 2011 Jun-Jul;11(5-6):345-8. doi: 10.1016/j.gep.2011.03.005. Epub 2011 Mar 31. Gene Expr Patterns. 2011. PMID: 21440093
Lmx1a is a member of the LIM homeodomain containing transcription factors and plays an important role during embryonic development. ...
Lmx1a is a member of the LIM homeodomain containing transcription factors and plays an important role during embryonic development. . …
Generation of animals allowing the conditional inactivation of the Pax4 gene.
Kordowich S, Serup P, Collombat P, Mansouri A. Kordowich S, et al. Among authors: mansouri a. Transgenic Res. 2012 Dec;21(6):1215-20. doi: 10.1007/s11248-012-9624-0. Epub 2012 Jun 21. Transgenic Res. 2012. PMID: 22717987 Free PMC article.
The analysis of loss- and gain-of-function mutant animals revealed that this factor plays a crucial role in the endocrine pancreas. ...
The analysis of loss- and gain-of-function mutant animals revealed that this factor plays a crucial role in the endocrine pancreas. . …
Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker.
Ahmad Z, Rafeeq M, Collombat P, Mansouri A. Ahmad Z, et al. Among authors: mansouri a. PLoS One. 2015 Dec 11;10(12):e0144597. doi: 10.1371/journal.pone.0144597. eCollection 2015. PLoS One. 2015. PMID: 26658466 Free PMC article.
Moreover, lineage-tracing experiments demonstrate that Pax6-deficient beta- and alpha-cells are shunted towards ghrelin marked cells, sustaining the idea that ghrelin may represent a marker for endocrine cell maturation....
Moreover, lineage-tracing experiments demonstrate that Pax6-deficient beta- and alpha-cells are shunted towards ghrelin marked cells, sustai …
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