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A putative receptor tyrosine kinase with unique structural topology.
Rescigno J, Mansukhani A, Basilico C. Rescigno J, et al. Among authors: mansukhani a. Oncogene. 1991 Oct;6(10):1909-13. Oncogene. 1991. PMID: 1840679
We have cloned a murine cDNA on the basis of homology to the tyrosine kinase domain of the bek fibroblast growth factor receptor. This cDNA encodes a putative tyrosine kinase receptor with a unique structural pattern in its extracellular domain. It is a
We have cloned a murine cDNA on the basis of homology to the tyrosine kinase domain of the bek fibroblast growth factor receptor. Thi …
Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ.
Huang Z, Marsiglia WM, Basu Roy U, Rahimi N, Ilghari D, Wang H, Chen H, Gai W, Blais S, Neubert TA, Mansukhani A, Traaseth NJ, Li X, Mohammadi M. Huang Z, et al. Among authors: mansukhani a. Mol Cell. 2016 Jan 7;61(1):98-110. doi: 10.1016/j.molcel.2015.11.010. Epub 2015 Dec 10. Mol Cell. 2016. PMID: 26687682 Free PMC article.
Mechanisms underlying differential responses to FGF signaling.
Dailey L, Ambrosetti D, Mansukhani A, Basilico C. Dailey L, et al. Among authors: mansukhani a. Cytokine Growth Factor Rev. 2005 Apr;16(2):233-47. doi: 10.1016/j.cytogfr.2005.01.007. Epub 2005 Mar 5. Cytokine Growth Factor Rev. 2005. PMID: 15863038 Review.
In this review we draw upon studies from the past fifteen years and attempt to construct a molecular picture of the different levels of regulation by which such specific cellular responses could be achieved by FGF signals. ...In particular we focus on the interaction with …
In this review we draw upon studies from the past fifteen years and attempt to construct a molecular picture of the different levels …
Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation.
Mansukhani A, Ambrosetti D, Holmes G, Cornivelli L, Basilico C. Mansukhani A, et al. J Cell Biol. 2005 Mar 28;168(7):1065-76. doi: 10.1083/jcb.200409182. Epub 2005 Mar 21. J Cell Biol. 2005. PMID: 15781477 Free PMC article.
We analyzed the gene expression profiles of osteoblasts expressing FGFR2 activating mutations (C342Y or S252W) and found a striking down-regulation of the expression of many Wnt target genes and a concomitant induction of the transcription factor Sox2. ...Sox2 assoc …
We analyzed the gene expression profiles of osteoblasts expressing FGFR2 activating mutations (C342Y or S252W) and found a striking d …
Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes.
Raucci A, Laplantine E, Mansukhani A, Basilico C. Raucci A, et al. Among authors: mansukhani a. J Biol Chem. 2004 Jan 16;279(3):1747-56. doi: 10.1074/jbc.M310384200. Epub 2003 Oct 30. J Biol Chem. 2004. PMID: 14593093
In this report we show that both the MEK-ERK1/2 and p38 MAPK pathways, but not phospholipase C gamma or phosphatidylinositol 3-kinase, play a role in FGF-mediated growth arrest of chondrocytes. ...FGF- and NGF-induced growth inhibition is accompanied by a strong and …
In this report we show that both the MEK-ERK1/2 and p38 MAPK pathways, but not phospholipase C gamma or phosphatidylinositol 3-kinase, play …
Sox2 is required for tumor development and cancer cell proliferation in osteosarcoma.
Maurizi G, Verma N, Gadi A, Mansukhani A, Basilico C. Maurizi G, et al. Among authors: mansukhani a. Oncogene. 2018 Aug;37(33):4626-4632. doi: 10.1038/s41388-018-0292-2. Epub 2018 May 10. Oncogene. 2018. PMID: 29743593 Free PMC article.
FGF signaling activates STAT1 and p21 and inhibits the estrogen response and proliferation of MCF-7 cells.
Johnson MR, Valentine C, Basilico C, Mansukhani A. Johnson MR, et al. Among authors: mansukhani a. Oncogene. 1998 May;16(20):2647-56. doi: 10.1038/sj.onc.1201789. Oncogene. 1998. PMID: 9632141
MCF-7 cells treated with FGFs exhibit slower growth than controls in both the presence and absence of estrogen, with a concomitant increase in the number of cells in G0/G1. Expression of a constitutively activated FGF receptor in these cells further decreases their …
MCF-7 cells treated with FGFs exhibit slower growth than controls in both the presence and absence of estrogen, with a concomitant in …
Mutation associated with Crouzon syndrome causes ligand-independent dimerization and activation of FGF receptor-2.
Mangasarian K, Li Y, Mansukhani A, Basilico C. Mangasarian K, et al. Among authors: mansukhani a. J Cell Physiol. 1997 Jul;172(1):117-25. doi: 10.1002/(SICI)1097-4652(199707)172:1<117::AID-JCP13>3.0.CO;2-9. J Cell Physiol. 1997. PMID: 9207932
By transfecting mutated and wild-type receptors into a variety of cell lines, we have shown that the C342Y mutation in FGFR-2 produces a receptor which is constitutively activated and capable of transforming NIH3T3 cells and preventing the differentiation of C2 myob …
By transfecting mutated and wild-type receptors into a variety of cell lines, we have shown that the C342Y mutation in FGFR-2 produce …
Activation of FGF receptors by mutations in the transmembrane domain.
Li Y, Mangasarian K, Mansukhani A, Basilico C. Li Y, et al. Among authors: mansukhani a. Oncogene. 1997 Mar 27;14(12):1397-406. doi: 10.1038/sj.onc.1200983. Oncogene. 1997. PMID: 9136983
Thus the transmembrane region of FGFR-2 and FGFR-3 plays a regulatory role in receptor function and the ACH mutation produces a dominant oversignaling receptor which is no longer regulated by FGF binding. These findings also support the newly identified role of FGF …
Thus the transmembrane region of FGFR-2 and FGFR-3 plays a regulatory role in receptor function and the ACH mutation produces a
Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding.
Roghani M, Mansukhani A, Dell'Era P, Bellosta P, Basilico C, Rifkin DB, Moscatelli D. Roghani M, et al. Among authors: mansukhani a. J Biol Chem. 1994 Feb 11;269(6):3976-84. J Biol Chem. 1994. PMID: 8307953
The role of heparin or heparan sulfates in the interaction of basic fibroblast growth factor (bFGF) with its high affinity receptor were investigated using purified extracellular ligand-binding region of FGF receptor-1 (FGFR-1) and intact receptors expressed in a myeloid c …
The role of heparin or heparan sulfates in the interaction of basic fibroblast growth factor (bFGF) with its high affinity receptor were inv …
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