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Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion.
Colombo MP, Mantovani A. Colombo MP, et al. Cancer Res. 2005 Oct 15;65(20):9113-6. doi: 10.1158/0008-5472.CAN-05-2714. Cancer Res. 2005. PMID: 16230363 Review.
RalB signaling: a bridge between inflammation and cancer.
Mantovani A, Balkwill F. Mantovani A, et al. Cell. 2006 Oct 6;127(1):42-4. doi: 10.1016/j.cell.2006.09.019. Cell. 2006. PMID: 17018274
A connection between the genetic events that lead to tumor formation and the signaling pathways of the innate immune response has been established. ...
A connection between the genetic events that lead to tumor formation and the signaling pathways of the innate immune response has bee
Cancer related inflammation: the macrophage connection.
Sica A, Allavena P, Mantovani A. Sica A, et al. Cancer Lett. 2008 Aug 28;267(2):204-15. doi: 10.1016/j.canlet.2008.03.028. Epub 2008 Apr 29. Cancer Lett. 2008. PMID: 18448242 Review.
The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches....
The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches....
Cancer and inflammation: a complex relationship.
Mantovani A, Pierotti MA. Mantovani A, et al. Cancer Lett. 2008 Aug 28;267(2):180-1. doi: 10.1016/j.canlet.2008.05.003. Epub 2008 Jun 17. Cancer Lett. 2008. PMID: 18562089 No abstract available.
The yin-yang of tumor-associated neutrophils.
Mantovani A. Mantovani A. Cancer Cell. 2009 Sep 8;16(3):173-4. doi: 10.1016/j.ccr.2009.08.014. Cancer Cell. 2009. PMID: 19732714
Cancer-related inflammation is a key component of the tumor microenvironment. A report in this issue of Cancer Cell now indicates that tumor-associated neutrophils in lung cancer can polarize to either "N1" or "N2" phenotype that inhibits or promotes cancer developm …
Cancer-related inflammation is a key component of the tumor microenvironment. A report in this issue of Cancer Cell now indica …
Cancer and inflammation: implications for pharmacology and therapeutics.
Balkwill F, Mantovani A. Balkwill F, et al. Clin Pharmacol Ther. 2010 Apr;87(4):401-6. doi: 10.1038/clpt.2009.312. Epub 2010 Mar 3. Clin Pharmacol Ther. 2010. PMID: 20200512 Review.
Smoldering, nonresolving inflammation is a component of the tumor microenvironment. The linkage between inflammation and cancer, first perceived in the nineteenth century, is now part of an accepted paradigm of carcinogenesis....
Smoldering, nonresolving inflammation is a component of the tumor microenvironment. The linkage between inflammation and cancer, firs …
Inflammation-mediated promotion of invasion and metastasis.
Solinas G, Marchesi F, Garlanda C, Mantovani A, Allavena P. Solinas G, et al. Cancer Metastasis Rev. 2010 Jun;29(2):243-8. doi: 10.1007/s10555-010-9227-2. Cancer Metastasis Rev. 2010. PMID: 20414701 Review.
Myelomonocytic cells are a key component of cancer-related inflammation. Tumor-associated macrophages and their mediators affect key elements in the multistep process of invasion and metastasis, from interaction with the extracellular matrix to the construction of a
Myelomonocytic cells are a key component of cancer-related inflammation. Tumor-associated macrophages and their mediators affect key …
Chemokines in cancer related inflammation.
Allavena P, Germano G, Marchesi F, Mantovani A. Allavena P, et al. Exp Cell Res. 2011 Mar 10;317(5):664-73. doi: 10.1016/j.yexcr.2010.11.013. Epub 2010 Dec 4. Exp Cell Res. 2011. PMID: 21134366 Review.
Evidence in pre-clinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies....
Evidence in pre-clinical and clinical settings suggests that the chemokine system represents a valuable target for the development of …
Cancer-related inflammation: common themes and therapeutic opportunities.
Balkwill FR, Mantovani A. Balkwill FR, et al. Semin Cancer Biol. 2012 Feb;22(1):33-40. doi: 10.1016/j.semcancer.2011.12.005. Epub 2011 Dec 24. Semin Cancer Biol. 2012. PMID: 22210179 Review.
However, macrophages are a common and fundamental component of cancer promoting inflammation. Drivers of macrophage functional orientation include tumor cells, cancer-associated fibroblasts, T cells and B cells. ...
However, macrophages are a common and fundamental component of cancer promoting inflammation. Drivers of macrophage functional orient …
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