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Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability.
Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A. Colotta F, et al. Among authors: mantovani a. Carcinogenesis. 2009 Jul;30(7):1073-81. doi: 10.1093/carcin/bgp127. Epub 2009 May 25. Carcinogenesis. 2009. PMID: 19468060 Review.
In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark....
In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI …
Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family.
Garlanda C, Riva F, Polentarutti N, Buracchi C, Sironi M, De Bortoli M, Muzio M, Bergottini R, Scanziani E, Vecchi A, Hirsch E, Mantovani A. Garlanda C, et al. Among authors: mantovani a. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3522-6. doi: 10.1073/pnas.0308680101. Epub 2004 Mar 1. Proc Natl Acad Sci U S A. 2004. PMID: 14993616 Free PMC article.
TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling pathway. ...Thus, TIR8 represents a negative pathway of regulation of the …
TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which act …
Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Mantovani A, Sozzani S, Locati M, Schioppa T, Saccani A, Allavena P, Sica A. Mantovani A, et al. Novartis Found Symp. 2004;256:137-45; discussion 146-8, 259-69. Novartis Found Symp. 2004. PMID: 15027487 Review.
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression....
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subvers …
Silent chemoattractant receptors: D6 as a decoy and scavenger receptor for inflammatory CC chemokines.
Locati M, Torre YM, Galliera E, Bonecchi R, Bodduluri H, Vago G, Vecchi A, Mantovani A. Locati M, et al. Among authors: mantovani a. Cytokine Growth Factor Rev. 2005 Dec;16(6):679-86. doi: 10.1016/j.cytogfr.2005.05.003. Epub 2005 Jul 5. Cytokine Growth Factor Rev. 2005. PMID: 15996892 Review.
D6 binds most inflammatory, but not homeostatic, CC chemokines and shuttles in a ligand-independent way from the plasma membrane to endocytic compartments where chemokines are targeted to degradation. In vitro and in vivo evidence, including results with gene-targeted mice …
D6 binds most inflammatory, but not homeostatic, CC chemokines and shuttles in a ligand-independent way from the plasma membrane to e …
Macrophage polarization comes of age.
Mantovani A, Sica A, Locati M. Mantovani A, et al. Immunity. 2005 Oct;23(4):344-6. doi: 10.1016/j.immuni.2005.10.001. Immunity. 2005. PMID: 16226499 Review.
Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion.
Colombo MP, Mantovani A. Colombo MP, et al. Among authors: mantovani a. Cancer Res. 2005 Oct 15;65(20):9113-6. doi: 10.1158/0008-5472.CAN-05-2714. Cancer Res. 2005. PMID: 16230363 Review.
Pentraxins as a key component of innate immunity.
Bottazzi B, Garlanda C, Salvatori G, Jeannin P, Manfredi A, Mantovani A. Bottazzi B, et al. Among authors: mantovani a. Curr Opin Immunol. 2006 Feb;18(1):10-5. doi: 10.1016/j.coi.2005.11.009. Epub 2005 Dec 15. Curr Opin Immunol. 2006. PMID: 16343883 Review.
Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. ...Evidence suggests that PTX3 acts as …
Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein …
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy.
Sica A, Schioppa T, Mantovani A, Allavena P. Sica A, et al. Among authors: mantovani a. Eur J Cancer. 2006 Apr;42(6):717-27. doi: 10.1016/j.ejca.2006.01.003. Epub 2006 Mar 7. Eur J Cancer. 2006. PMID: 16520032 Review.
The pro-tumoural role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage content of tumours and poor patient prognosis. Evidence is presented here supporting the view that TAM represent a unique and distinc …
The pro-tumoural role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage …
Role of tumor-associated macrophages in tumor progression and invasion.
Mantovani A, Schioppa T, Porta C, Allavena P, Sica A. Mantovani A, et al. Cancer Metastasis Rev. 2006 Sep;25(3):315-22. doi: 10.1007/s10555-006-9001-7. Cancer Metastasis Rev. 2006. PMID: 16967326 Review.
The protumoral role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage content of tumors and poor patient prognosis and by evidence showing that long-term use of non-steroidal anti-inflammatory drugs reduces the r …
The protumoral role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage co …
RalB signaling: a bridge between inflammation and cancer.
Mantovani A, Balkwill F. Mantovani A, et al. Cell. 2006 Oct 6;127(1):42-4. doi: 10.1016/j.cell.2006.09.019. Cell. 2006. PMID: 17018274
A connection between the genetic events that lead to tumor formation and the signaling pathways of the innate immune response has been established. ...
A connection between the genetic events that lead to tumor formation and the signaling pathways of the innate immune response has bee
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