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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.
Biswas SK, Mantovani A. Biswas SK, et al. Nat Immunol. 2010 Oct;11(10):889-96. doi: 10.1038/ni.1937. Epub 2010 Sep 20. Nat Immunol. 2010. PMID: 20856220 Review.
The orchestration of myelomonocytic cell function is a key element that links inflammation and cancer and provides a paradigm for macrophage plasticity and function. A better understanding of the molecular basis of myelomonocytic cell plasticity will open new …
The orchestration of myelomonocytic cell function is a key element that links inflammation and cancer and provides a paradigm …
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch.
Lee JS, Cella M, McDonald KG, Garlanda C, Kennedy GD, Nukaya M, Mantovani A, Kopan R, Bradfield CA, Newberry RD, Colonna M. Lee JS, et al. Nat Immunol. 2011 Nov 20;13(2):144-51. doi: 10.1038/ni.2187. Nat Immunol. 2011. PMID: 22101730 Free PMC article.
Here we found that Ahr(-/-) mice had a considerable deficit in ILC22 cells that resulted in less secretion of IL-22 and inadequate protection against intestinal bacterial infection. ...
Here we found that Ahr(-/-) mice had a considerable deficit in ILC22 cells that resulted in less secretion of IL-22 and inadequate pr …
B cells and macrophages in cancer: yin and yang.
Mantovani A. Mantovani A. Nat Med. 2011 Mar;17(3):285-6. doi: 10.1038/nm0311-285. Nat Med. 2011. PMID: 21383737 No abstract available.
Cancer: Inflaming metastasis.
Mantovani A. Mantovani A. Nature. 2009 Jan 1;457(7225):36-7. doi: 10.1038/457036b. Nature. 2009. PMID: 19122629 No abstract available.
Cancer: an infernal triangle.
Mantovani A. Mantovani A. Nature. 2007 Aug 2;448(7153):547-8. doi: 10.1038/448547a. Nature. 2007. PMID: 17671495 No abstract available.
Cancer-related inflammation.
Mantovani A, Allavena P, Sica A, Balkwill F. Mantovani A, et al. Nature. 2008 Jul 24;454(7203):436-44. doi: 10.1038/nature07205. Nature. 2008. PMID: 18650914 Review.
In some types of cancer, inflammatory conditions are present before a malignant change occurs. Conversely, in other types of cancer, an oncogenic change induces an inflammatory microenvironment that promotes the development of tumours. ...
In some types of cancer, inflammatory conditions are present before a malignant change occurs. Conversely, in other types of cancer, …
IL-1 family nomenclature.
Dinarello C, Arend W, Sims J, Smith D, Blumberg H, O'Neill L, Goldbach-Mansky R, Pizarro T, Hoffman H, Bufler P, Nold M, Ghezzi P, Mantovani A, Garlanda C, Boraschi D, Rubartelli A, Netea M, van der Meer J, Joosten L, Mandrup-Poulsen T, Donath M, Lewis E, Pfeilschifter J, Martin M, Kracht M, Muehl H, Novick D, Lukic M, Conti B, Solinger A, Kelk P, van de Veerdonk F, Gabel C. Dinarello C, et al. Nat Immunol. 2010 Nov;11(11):973. doi: 10.1038/ni1110-973. Nat Immunol. 2010. PMID: 20959797 Free PMC article. No abstract available.
Failure to detect production of IL-10 by activated human neutrophils.
Davey MS, Tamassia N, Rossato M, Bazzoni F, Calzetti F, Bruderek K, Sironi M, Zimmer L, Bottazzi B, Mantovani A, Brandau S, Moser B, Eberl M, Cassatella MA. Davey MS, et al. Nat Immunol. 2011 Oct 19;12(11):1017-8; author reply 1018-20. doi: 10.1038/ni.2111. Nat Immunol. 2011. PMID: 22012430 No abstract available.
IL-10 limits production of pathogenic TNF by M1 myeloid cells through induction of nuclear NF-κB p50 member in Trypanosoma congolense infection-resistant C57BL/6 mice.
Bosschaerts T, Morias Y, Stijlemans B, Hérin M, Porta C, Sica A, Mantovani A, De Baetselier P, Beschin A. Bosschaerts T, et al. Eur J Immunol. 2011 Nov;41(11):3270-80. doi: 10.1002/eji.201041307. Epub 2011 Sep 19. Eur J Immunol. 2011. PMID: 21805465
A balance between parasite elimination and control of infection-associated pathogenicity is crucial for resistance to African trypanosomiasis. By producing TNF and NO, CD11b(+) myeloid cells with a classical activation status (M1) contribute to parasitemia control i
A balance between parasite elimination and control of infection-associated pathogenicity is crucial for resistance to African trypano
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