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Macrophage plasticity and polarization: in vivo veritas.
Sica A, Mantovani A. Sica A, et al. Among authors: mantovani a. J Clin Invest. 2012 Mar;122(3):787-95. doi: 10.1172/JCI59643. Epub 2012 Mar 1. J Clin Invest. 2012. PMID: 22378047 Free PMC article. Review.
In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a continuum in a universe of activation states. ...The identification of mechanisms and molecu …
In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) activati …
Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Mantovani A, Sozzani S, Locati M, Schioppa T, Saccani A, Allavena P, Sica A. Mantovani A, et al. Novartis Found Symp. 2004;256:137-45; discussion 146-8, 259-69. Novartis Found Symp. 2004. PMID: 15027487 Review.
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression....
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subvers …
Macrophage polarization comes of age.
Mantovani A, Sica A, Locati M. Mantovani A, et al. Immunity. 2005 Oct;23(4):344-6. doi: 10.1016/j.immuni.2005.10.001. Immunity. 2005. PMID: 16226499 Review.
Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion.
Colombo MP, Mantovani A. Colombo MP, et al. Among authors: mantovani a. Cancer Res. 2005 Oct 15;65(20):9113-6. doi: 10.1158/0008-5472.CAN-05-2714. Cancer Res. 2005. PMID: 16230363 Review.
The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility.
Bottazzi B, Bastone A, Doni A, Garlanda C, Valentino S, Deban L, Maina V, Cotena A, Moalli F, Vago L, Salustri A, Romani L, Mantovani A. Bottazzi B, et al. Among authors: mantovani a. J Leukoc Biol. 2006 May;79(5):909-12. doi: 10.1189/jlb.1005557. Epub 2006 Feb 14. J Leukoc Biol. 2006. PMID: 16478917 Review.
The long pentraxin 3 (PTX3) is member of a complex superfamily of multifunctional proteins characterized by a cyclic multimeric structure. ...Thus, the prototypic long pentraxin PTX3 is a multifunctional, soluble pattern recognition receptor acting as a
The long pentraxin 3 (PTX3) is member of a complex superfamily of multifunctional proteins characterized by a cyclic multimeri …
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy.
Sica A, Schioppa T, Mantovani A, Allavena P. Sica A, et al. Among authors: mantovani a. Eur J Cancer. 2006 Apr;42(6):717-27. doi: 10.1016/j.ejca.2006.01.003. Epub 2006 Mar 7. Eur J Cancer. 2006. PMID: 16520032 Review.
The pro-tumoural role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage content of tumours and poor patient prognosis. Evidence is presented here supporting the view that TAM represent a unique and distinc …
The pro-tumoural role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage …
Role of tumor-associated macrophages in tumor progression and invasion.
Mantovani A, Schioppa T, Porta C, Allavena P, Sica A. Mantovani A, et al. Cancer Metastasis Rev. 2006 Sep;25(3):315-22. doi: 10.1007/s10555-006-9001-7. Cancer Metastasis Rev. 2006. PMID: 16967326 Review.
The protumoral role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage content of tumors and poor patient prognosis and by evidence showing that long-term use of non-steroidal anti-inflammatory drugs reduces the r …
The protumoral role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage co …
RalB signaling: a bridge between inflammation and cancer.
Mantovani A, Balkwill F. Mantovani A, et al. Cell. 2006 Oct 6;127(1):42-4. doi: 10.1016/j.cell.2006.09.019. Cell. 2006. PMID: 17018274
A connection between the genetic events that lead to tumor formation and the signaling pathways of the innate immune response has been established. ...
A connection between the genetic events that lead to tumor formation and the signaling pathways of the innate immune response has bee
The long pentraxin PTX3 in vascular pathology.
Mantovani A, Garlanda C, Bottazzi B, Peri G, Doni A, Martinez de la Torre Y, Latini R. Mantovani A, et al. Vascul Pharmacol. 2006 Nov;45(5):326-30. doi: 10.1016/j.vph.2006.08.011. Epub 2006 Aug 23. Vascul Pharmacol. 2006. PMID: 17023219 Review.
Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. ...PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, …
Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic mul …
The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses.
Borroni EM, Buracchi C, de la Torre YM, Galliera E, Vecchi A, Bonecchi R, Mantovani A, Locati M. Borroni EM, et al. Among authors: mantovani a. Biochem Soc Trans. 2006 Dec;34(Pt 6):1014-7. doi: 10.1042/BST0341014. Biochem Soc Trans. 2006. PMID: 17073740
Structure-function analysis and recent results with gene-targeted animals indicate that D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium and pl …
Structure-function analysis and recent results with gene-targeted animals indicate that D6 has unique functional and structural features, wh …
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