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Cytokines as communication signals between leukocytes and endothelial cells.
Mantovani A, Dejana E. Mantovani A, et al. Immunol Today. 1989 Nov;10(11):370-5. doi: 10.1016/0167-5699(89)90270-3. Immunol Today. 1989. PMID: 2514701 Review.
In this review, Alberto Mantovani and Elisabetta Dejana discuss endothelial cells as important participants in the induction and regulation of coagulation, inflammation and immunity and cytokines as crucial mediators of the symbiotic interactions between vascular cells and …
In this review, Alberto Mantovani and Elisabetta Dejana discuss endothelial cells as important participants in the induction and regu …
Migratory response of human natural killer cells to lymphotactin.
Giancarlo B, Silvano S, Albert Z, Mantovani A, Allavena P. Giancarlo B, et al. Eur J Immunol. 1996 Dec;26(12):3238-41. doi: 10.1002/eji.1830261260. Eur J Immunol. 1996. PMID: 8977329
Lymphotactin (Lptn) is a new protein belonging to the C or gamma subfamily of chemokines with only two of the four cysteine residues. ...Migration in response to Lptn was chemotaxis rather than chemokinesis as determined in a checkerboard analysis. Migration of NK c …
Lymphotactin (Lptn) is a new protein belonging to the C or gamma subfamily of chemokines with only two of the four cysteine residues. …
IL-1 stimulates IL-6 production in endothelial cells.
Sironi M, Breviario F, Proserpio P, Biondi A, Vecchi A, Van Damme J, Dejana E, Mantovani A. Sironi M, et al. J Immunol. 1989 Jan 15;142(2):549-53. J Immunol. 1989. PMID: 2783442
The present study was designed to define the possible role of IL-6 as a communication signal between vascular and immunocompetent cells. ...Inasmuch as IL-1 elicits a complex series of changes in HEC, it was important to assess whether IL-6, produced after exposure …
The present study was designed to define the possible role of IL-6 as a communication signal between vascular and immunocompetent cel …
In vitro and in vivo activation of endothelial cells by colony-stimulating factors.
Bussolino F, Ziche M, Wang JM, Alessi D, Morbidelli L, Cremona O, Bosia A, Marchisio PC, Mantovani A. Bussolino F, et al. J Clin Invest. 1991 Mar;87(3):986-95. doi: 10.1172/JCI115107. J Clin Invest. 1991. PMID: 1705569 Free PMC article.
Exposure to both cytokines induced shape changes and cytoskeletal reorganization consistent with a migratory phenotype. To explore the in vivo relevance of the in vitro effects of these cytokines on endothelium, we studied the angiogenic activity of human G-CSF in the rabb …
Exposure to both cytokines induced shape changes and cytoskeletal reorganization consistent with a migratory phenotype. To explore th …
The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1.
Colotta F, Dower SK, Sims JE, Mantovani A. Colotta F, et al. Immunol Today. 1994 Dec;15(12):562-6. doi: 10.1016/0167-5699(94)90217-8. Immunol Today. 1994. PMID: 7848516 Review.
The interleukin 1 (IL-1) system plays a central role in inflammation and immunity. Of the two receptors that bind IL-1, the type I receptor is known to mediate signaling activity, whereas the function of the type II receptor remains unknown. Here, Francesco Colotta and col …
The interleukin 1 (IL-1) system plays a central role in inflammation and immunity. Of the two receptors that bind IL-1, the type I re …
Recent developments in the cell biology of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor: activities on endothelial cells.
Bussolino F, Colotta F, Bocchietto E, Guglielmetti A, Mantovani A. Bussolino F, et al. Int J Clin Lab Res. 1993;23(1):8-12. doi: 10.1007/BF02592273. Int J Clin Lab Res. 1993. PMID: 7682862 Review.
Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells.
Polentarutti N, Introna M, Sozzani S, Mancinelli R, Mantovani G, Mantovani A. Polentarutti N, et al. Eur Cytokine Netw. 1997 Sep;8(3):271-4. Eur Cytokine Netw. 1997. PMID: 9346360
Monocyte chemotactic protein-3 (MCP-3) is a C-C chemokine which interacts with the CCR1, CCR2 (MCP-1) and CCR3 receptors and has a distinct spectrum of action. ...Interferon-gamma was a much weaker, but nevertheless active, inducer. MCP-3 transcripts were con …
Monocyte chemotactic protein-3 (MCP-3) is a C-C chemokine which interacts with the CCR1, CCR2 (MCP-1) and CCR3 receptors and has a
TNF-alpha, unlike other pro- and anti-inflammatory cytokines, induces rapid release of the IL-1 type II decoy receptor in human myelomonocytic cells.
Orlando S, Matteucci C, Fadlon EJ, Buurman WA, Bardella MT, Colotta F, Introna M, Mantovani A. Orlando S, et al. J Immunol. 1997 Apr 15;158(8):3861-8. J Immunol. 1997. PMID: 9103454
The present study was designed to investigate the effect of a series of cytokines on the release of the type II IL-1 decoy receptor, which represents a unique pathway of negative regulation of the IL-1 system. ...Monocytes showed a similar response to TNF, ex …
The present study was designed to investigate the effect of a series of cytokines on the release of the type II IL-1 decoy receptor, …
Divergent effects of interleukin-10 on cytokine production by mononuclear phagocytes and endothelial cells.
Sironi M, Muñoz C, Pollicino T, Siboni A, Sciacca FL, Bernasconi S, Vecchi A, Colotta F, Mantovani A. Sironi M, et al. Eur J Immunol. 1993 Oct;23(10):2692-5. doi: 10.1002/eji.1830231046. Eur J Immunol. 1993. PMID: 8405067
Interleukin-10 (IL-10), a product of T helper type 2 (TH2) cells and monocytes, inhibits cytokine production in mononuclear phagocytes. ...The selective inhibitory action of IL-10 on mononuclear phagocytes versus endothelial cells may play a role in the pathophysiol …
Interleukin-10 (IL-10), a product of T helper type 2 (TH2) cells and monocytes, inhibits cytokine production in mononuclear phagocyte …
The recruitment of leukocytes and their interaction with the vessel wall: the role of interleukin-1 and tumor necrosis factor.
Dejana E, Ji-Ming W, Mantovani A. Dejana E, et al. Scand J Rheumatol Suppl. 1987;66:19-25. doi: 10.3109/03009748709102518. Scand J Rheumatol Suppl. 1987. PMID: 3502509
TNF, released in tissues may act as a chemoattractant and further promote interaction of leukocytes with the vascular lining. IL-1 and TNF can therefore act as a communications signal between circulating cells and the vessel wall and play an important role in the in …
TNF, released in tissues may act as a chemoattractant and further promote interaction of leukocytes with the vascular lining. IL-1 an …
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