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Protective effects of the PPAR agonist bezafibrate against disruption of redox and energy homeostasis, neuronal death, astroglial reactivity, and neuroinflammation induced in vivo by D-2-hydroxyglutaric acid in rat brain.
Ribeiro RT, Marcuzzo MB, Carvalho AVS, Palavro R, Castro ET, Pinheiro CV, Bobermin LD, Amaral AU, Leipnitz G, Netto CA, Wajner M. Ribeiro RT, et al. Among authors: marcuzzo mb. Eur J Pharmacol. 2025 Jan 15;987:177186. doi: 10.1016/j.ejphar.2024.177186. Epub 2024 Dec 6. Eur J Pharmacol. 2025. PMID: 39647572
Sulfite Impairs Bioenergetics and Redox Status in Neonatal Rat Brain: Insights into the Early Neuropathophysiology of Isolated Sulfite Oxidase and Molybdenum Cofactor Deficiencies.
Pramio J, Grings M, da Rosa AG, Ribeiro RT, Glanzel NM, Signori MF, Marcuzzo MB, Bobermin LD, Wyse ATS, Quincozes-Santos A, Wajner M, Leipnitz G. Pramio J, et al. Among authors: marcuzzo mb. Cell Mol Neurobiol. 2023 Aug;43(6):2895-2907. doi: 10.1007/s10571-023-01328-6. Epub 2023 Mar 2. Cell Mol Neurobiol. 2023. PMID: 36862242 Free PMC article.
3-Hydroxy-3-Methylglutaric Acid Disrupts Brain Bioenergetics, Redox Homeostasis, and Mitochondrial Dynamics and Affects Neurodevelopment in Neonatal Wistar Rats.
Silveira JA, Marcuzzo MB, da Rosa JS, Kist NS, Hoffmann CIH, Carvalho AS, Ribeiro RT, Quincozes-Santos A, Netto CA, Wajner M, Leipnitz G. Silveira JA, et al. Among authors: marcuzzo mb. Biomedicines. 2024 Jul 15;12(7):1563. doi: 10.3390/biomedicines12071563. Biomedicines. 2024. PMID: 39062136 Free PMC article.
Increased ROS levels, antioxidant defense disturbances and bioenergetic disruption induced by thiosulfate administration in the brain of neonatal rats.
Glänzel NM, da Rosa-Junior NT, Signori MF, de Andrade Silveira J, Pinheiro CV, Marcuzzo MB, Campos-Carraro C, da Rosa Araujo AS, Schiöth HB, Wajner M, Leipnitz G. Glänzel NM, et al. Among authors: marcuzzo mb. Metab Brain Dis. 2024 Dec 20;40(1):73. doi: 10.1007/s11011-024-01510-9. Metab Brain Dis. 2024. PMID: 39704910