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234 results
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Guilty as charged: B-RAF is a human oncogene.
Garnett MJ, Marais R. Garnett MJ, et al. Among authors: marais r. Cancer Cell. 2004 Oct;6(4):313-9. doi: 10.1016/j.ccr.2004.09.022. Cancer Cell. 2004. PMID: 15488754 Review.
MEK kinase activity is not necessary for Raf-1 function.
Hüser M, Luckett J, Chiloeches A, Mercer K, Iwobi M, Giblett S, Sun XM, Brown J, Marais R, Pritchard C. Hüser M, et al. Among authors: marais r. EMBO J. 2001 Apr 17;20(8):1940-51. doi: 10.1093/emboj/20.8.1940. EMBO J. 2001. PMID: 11296227 Free PMC article.
Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1.
Clerk A, Pham FH, Fuller SJ, Sahai E, Aktories K, Marais R, Marshall C, Sugden PH. Clerk A, et al. Among authors: marais r. Mol Cell Biol. 2001 Feb;21(4):1173-84. doi: 10.1128/MCB.21.4.1173-1184.2001. Mol Cell Biol. 2001. PMID: 11158304 Free PMC article.
Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras.
Chiloeches A, Paterson HF, Marais R, Clerk A, Marshall CJ, Sugden PH. Chiloeches A, et al. Among authors: marais r. J Biol Chem. 1999 Jul 9;274(28):19762-70. doi: 10.1074/jbc.274.28.19762. J Biol Chem. 1999. PMID: 10391918
Ras protein signalling.
Olson MF, Marais R. Olson MF, et al. Among authors: marais r. Semin Immunol. 2000 Feb;12(1):63-73. doi: 10.1006/smim.2000.0208. Semin Immunol. 2000. PMID: 10723799 Review.
Erythropoietin-stimulated Raf-1 tyrosine phosphorylation is associated with the tyrosine kinase Lyn in J2E erythroleukemic cells.
Tilbrook PA, Colley SM, McCarthy DJ, Marais R, Klinken SP. Tilbrook PA, et al. Among authors: marais r. Arch Biochem Biophys. 2001 Dec 1;396(1):128-32. doi: 10.1006/abbi.2001.2577. Arch Biochem Biophys. 2001. PMID: 11716471
ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers.
Rebocho AP, Marais R. Rebocho AP, et al. Among authors: marais r. Oncogene. 2013 Jun 27;32(26):3207-12. doi: 10.1038/onc.2012.330. Epub 2012 Aug 27. Oncogene. 2013. PMID: 22926515
A novel vascular endothelial growth factor-directed therapy that selectively activates cytotoxic prodrugs.
Spooner RA, Friedlos F, Maycroft K, Stribbling SM, Roussel J, Brueggen J, Stolz B, O'Reilly T, Wood J, Matter A, Marais R, Springer CJ. Spooner RA, et al. Among authors: marais r. Br J Cancer. 2003 May 19;88(10):1622-30. doi: 10.1038/sj.bjc.6600911. Br J Cancer. 2003. PMID: 12771932 Free PMC article.
Appropriate subcellular localisation of prodrug-activating enzymes has important consequences for suicide gene therapy.
Spooner RA, Maycroft KA, Paterson H, Friedlos F, Springer CJ, Marais R. Spooner RA, et al. Among authors: marais r. Int J Cancer. 2001 Jul 1;93(1):123-30. doi: 10.1002/ijc.1288. Int J Cancer. 2001. PMID: 11391631
In suicide gene therapy, the site of subcellular localization of the activating enzyme is more important than the rate at which it activates prodrug.
Spooner RA, Martin J, Friedlos F, Marais R, Springer CJ. Spooner RA, et al. Among authors: marais r. Cancer Gene Ther. 2000 Oct;7(10):1348-56. doi: 10.1038/sj.cgt.7700243. Cancer Gene Ther. 2000. PMID: 11059693
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