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Mitochondrial death functions of p53.
Marchenko ND, Moll UM. Marchenko ND, et al. Mol Cell Oncol. 2014 Oct 31;1(2):e955995. doi: 10.1080/23723548.2014.955995. eCollection 2014 Apr-Jun. Mol Cell Oncol. 2014. PMID: 27308326 Free PMC article. Review.
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis.
Li D, Marchenko ND, Moll UM. Li D, et al. Among authors: marchenko nd. Cell Death Differ. 2011 Dec;18(12):1904-13. doi: 10.1038/cdd.2011.71. Epub 2011 Jun 3. Cell Death Differ. 2011. PMID: 21637290 Free PMC article.
Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors.
Vaseva AV, Yallowitz AR, Marchenko ND, Xu S, Moll UM. Vaseva AV, et al. Among authors: marchenko nd. Cell Death Dis. 2011 May 12;2(5):e156. doi: 10.1038/cddis.2011.39. Cell Death Dis. 2011. PMID: 21562588 Free PMC article.
Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha3 binding.
Marchenko ND, Hanel W, Li D, Becker K, Reich N, Moll UM. Marchenko ND, et al. Cell Death Differ. 2010 Feb;17(2):255-67. doi: 10.1038/cdd.2009.173. Epub 2009 Nov 20. Cell Death Differ. 2010. PMID: 19927155 Free PMC article.
Loss of p53 function in uterine papillary serous carcinoma.
Kovalev S, Marchenko ND, Gugliotta BG, Chalas E, Chumas J, Moll UM. Kovalev S, et al. Hum Pathol. 1998 Jun;29(6):613-9. doi: 10.1016/s0046-8177(98)80012-9. Hum Pathol. 1998. PMID: 9635683
p53 opens the mitochondrial permeability transition pore to trigger necrosis.
Vaseva AV, Marchenko ND, Ji K, Tsirka SE, Holzmann S, Moll UM. Vaseva AV, et al. Among authors: marchenko nd. Cell. 2012 Jun 22;149(7):1536-48. doi: 10.1016/j.cell.2012.05.014. Cell. 2012. PMID: 22726440 Free PMC article.
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