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GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.
Nogueira TC, Paula FM, Villate O, Colli ML, Moura RF, Cunha DA, Marselli L, Marchetti P, Cnop M, Julier C, Eizirik DL. Nogueira TC, et al. Among authors: marchetti p. PLoS Genet. 2013 May;9(5):e1003532. doi: 10.1371/journal.pgen.1003532. Epub 2013 May 30. PLoS Genet. 2013. PMID: 23737756 Free PMC article.
Effects of prolonged exposure to pancreatic glucagon on the function, antigenicity and survival of isolated human islets.
Del Guerra S, Lupi R, Dotta F, Marselli L, Lencioni C, Santangelo C, Realacci M, Carmellini M, Mosca F, Navalesi R, Marchetti P. Del Guerra S, et al. Among authors: marchetti p. Diabetes Metab Res Rev. 2000 Jul-Aug;16(4):281-6. doi: 10.1002/1520-7560(2000)9999:9999<::aid-dmrr124>3.0.co;2-q. Diabetes Metab Res Rev. 2000. PMID: 10934457
Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines.
Marselli L, Dotta F, Piro S, Santangelo C, Masini M, Lupi R, Realacci M, del Guerra S, Mosca F, Boggi U, Purrello F, Navalesi R, Marchetti P. Marselli L, et al. Among authors: marchetti p. J Clin Endocrinol Metab. 2001 Oct;86(10):4974-8. doi: 10.1210/jcem.86.10.7938. J Clin Endocrinol Metab. 2001. PMID: 11600573
NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro.
Pierucci D, Cicconi S, Bonini P, Ferrelli F, Pastore D, Matteucci C, Marselli L, Marchetti P, Ris F, Halban P, Oberholzer J, Federici M, Cozzolino F, Lauro R, Borboni P, Marlier LN. Pierucci D, et al. Among authors: marchetti p. Diabetologia. 2001 Oct;44(10):1281-95. doi: 10.1007/s001250100650. Diabetologia. 2001. PMID: 11692177
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.
Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P. Lupi R, et al. Among authors: marchetti p. Diabetes. 2002 May;51(5):1437-42. doi: 10.2337/diabetes.51.5.1437. Diabetes. 2002. PMID: 11978640
1,441 results