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The oncogenic tyrosine kinase Lyn impairs the pro-apoptotic function of Bim.
Aira LE, Villa E, Colosetti P, Gamas P, Signetti L, Obba S, Proics E, Gautier F, Bailly-Maitre B, Jacquel A, Robert G, Luciano F, Juin PP, Ricci JE, Auberger P, Marchetti S. Aira LE, et al. Among authors: marchetti s. Oncogene. 2018 Apr;37(16):2122-2136. doi: 10.1038/s41388-017-0112-0. Epub 2018 Feb 2. Oncogene. 2018. PMID: 29391601
BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice.
Hamouda MA, Jacquel A, Robert G, Puissant A, Richez V, Cassel R, Fenouille N, Roulland S, Gilleron J, Griessinger E, Dubois A, Bailly-Maitre B, Goncalves D, Mallavialle A, Colosetti P, Marchetti S, Amiot M, Gomez-Bougie P, Rochet N, Deckert M, Avet-Loiseau H, Hofman P, Karsenti JM, Jeandel PY, Blin-Wakkach C, Nadel B, Cluzeau T, Anderson KC, Fuzibet JG, Auberger P, Luciano F. Hamouda MA, et al. Among authors: marchetti s. J Exp Med. 2016 Aug 22;213(9):1705-22. doi: 10.1084/jem.20150983. Epub 2016 Jul 25. J Exp Med. 2016. PMID: 27455953 Free PMC article.
ATP-competitive Plk1 inhibitors induce caspase 3-mediated Plk1 cleavage and activation in hematopoietic cell lines.
Dufies M, Ambrosetti D, Boulakirba S, Calleja A, Savy C, Furstoss N, Zerhouni M, Parola J, Aira-Diaz L, Marchetti S, Orange F, Lacas-Gervais S, Luciano F, Jacquel A, Robert G, Pagès G, Auberger P. Dufies M, et al. Among authors: marchetti s. Oncotarget. 2017 Dec 23;9(13):10920-10933. doi: 10.18632/oncotarget.23650. eCollection 2018 Feb 16. Oncotarget. 2017. PMID: 29541386 Free PMC article.
The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice.
Marchetti S, Gamas P, Belhacène N, Grosso S, Pradelli LA, Colosetti P, Johansen C, Iversen L, Deckert M, Luciano F, Hofman P, Ortonne N, Khemis A, Mari B, Ortonne JP, Ricci JE, Auberger P. Marchetti S, et al. EMBO J. 2009 Aug 19;28(16):2449-60. doi: 10.1038/emboj.2009.183. Epub 2009 Jul 9. EMBO J. 2009. PMID: 19590497 Free PMC article.
280 results