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The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.
de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A. de Thé H, et al. Among authors: marchio a. Cell. 1991 Aug 23;66(4):675-84. doi: 10.1016/0092-8674(91)90113-d. Cell. 1991. PMID: 1652369
We report here that this gene product contains a novel zinc finger motif common to several DNA-binding proteins. The PML-RAR alpha mRNA encodes a predicted 106 kd chimeric protein containing most of the PML sequences fused to a large part of RAR alpha, includ …
We report here that this gene product contains a novel zinc finger motif common to several DNA-binding proteins. The PML-RAR alpha mR …
Chromosomal abnormalities in liver cell dysplasia detected by comparative genomic hybridisation.
Marchio A, Terris B, Meddeb M, Pineau P, Duverger A, Tiollais P, Bernheim A, Dejean A. Marchio A, et al. Mol Pathol. 2001 Aug;54(4):270-4. doi: 10.1136/mp.54.4.270. Mol Pathol. 2001. PMID: 11477144 Free PMC article.
The aim of this study was to determine whether there is a genetic link between liver cell dysplasia and HCC that could support the role of dysplasia as a tumour precursor lesion. ...In contrast, a subset of chromosomal alterations present in HCCs was found in …
The aim of this study was to determine whether there is a genetic link between liver cell dysplasia and HCC that could support the ro …
Identification of a second human retinoic acid receptor.
Brand N, Petkovich M, Krust A, Chambon P, de Thé H, Marchio A, Tiollais P, Dejean A. Brand N, et al. Among authors: marchio a. Nature. 1988 Apr 28;332(6167):850-3. doi: 10.1038/332850a0. Nature. 1988. PMID: 2833708
We have previously described a human complementary DNA that encodes a novel protein which is homologous to members of the steroid/thyroid nuclear receptor multigene family. ...To test the possibility that the hap protein might also be a retinoid receptor, …
We have previously described a human complementary DNA that encodes a novel protein which is homologous to members of the ster …
Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3.
Mattei MG, de Thé H, Mattei JF, Marchio A, Tiollais P, Dejean A. Mattei MG, et al. Among authors: marchio a. Hum Genet. 1988 Oct;80(2):189-90. doi: 10.1007/BF00702867. Hum Genet. 1988. PMID: 2844650
Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients.
Marchio A, Pineau P, Meddeb M, Terris B, Tiollais P, Bernheim A, Dejean A. Marchio A, et al. Oncogene. 2000 Aug 3;19(33):3733-8. doi: 10.1038/sj.onc.1203713. Oncogene. 2000. PMID: 10949927
Thus, in addition to a common pathway towards malignancy, a subset of alterations may preferentially contribute to virus-induced carcinogenesis. In a parallel CGH study of 10 fibrolamellar carcinomas, a rare subtype of HCC, we found in six out of the s …
Thus, in addition to a common pathway towards malignancy, a subset of alterations may preferentially contribute to virus-induc …
Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment.
Seeler JS, Marchio A, Sitterlin D, Transy C, Dejean A. Seeler JS, et al. Among authors: marchio a. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7316-21. doi: 10.1073/pnas.95.13.7316. Proc Natl Acad Sci U S A. 1998. PMID: 9636146 Free PMC article.
Further, we demonstrate that a naturally occurring splice variant of SP100, here called SP100-HMG, is a member of the high mobility group-1 (HMG-1) protein family and may thus possess DNA-binding potential. ...They support a model in which the NBs may play …
Further, we demonstrate that a naturally occurring splice variant of SP100, here called SP100-HMG, is a member of the high mob …
Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization.
Marchio A, Meddeb M, Pineau P, Danglot G, Tiollais P, Bernheim A, Dejean A. Marchio A, et al. Genes Chromosomes Cancer. 1997 Jan;18(1):59-65. Genes Chromosomes Cancer. 1997. PMID: 8993981
In a few cases, sequence amplifications were detected that were mapped to bands 11q12, 12p11, 14q12, and 19q13.1. This study represents the first analysis of primary liver cancers by CGH, and it confirms the presence of previously known chromosomal aberrations in HCC and h …
In a few cases, sequence amplifications were detected that were mapped to bands 11q12, 12p11, 14q12, and 19q13.1. This study represen …
The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice.
David G, Terris B, Marchio A, Lavau C, Dejean A. David G, et al. Among authors: marchio a. Oncogene. 1997 Apr 3;14(13):1547-54. doi: 10.1038/sj.onc.1200989. Oncogene. 1997. PMID: 9129145
The PML-RAR alpha hybrid protein generated by the t(15;17) translocation in acute promyelocytic leukemia (APL) is thought to play a central role in the oncogenic process. ...After 5 days zinc stimulation, 27 out of 54 mice developed hepatic preneoplasia and neoplasia inclu …
The PML-RAR alpha hybrid protein generated by the t(15;17) translocation in acute promyelocytic leukemia (APL) is thought to play a c …
Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification.
Seeler JS, Marchio A, Losson R, Desterro JM, Hay RT, Chambon P, Dejean A. Seeler JS, et al. Among authors: marchio a. Mol Cell Biol. 2001 May;21(10):3314-24. doi: 10.1128/MCB.21.10.3314-3324.2001. Mol Cell Biol. 2001. PMID: 11313457 Free PMC article.
In exploring the functional relationships between NBs and chromatin, we have shown previously that SP100 interacts with members of the HP1 family of nonhistone chromosomal proteins and that a variant SP100 cDNA encodes a high-mobility group (HMG1/2) protein. ...We f …
In exploring the functional relationships between NBs and chromatin, we have shown previously that SP100 interacts with members of the HP1 f …
Extensive analysis of duplicated-inverted hepatitis B virus integrations in human hepatocellular carcinoma.
Pineau P, Marchio A, Mattei MG, Kim WH, Youn JK, Tiollais P, Dejean A. Pineau P, et al. Among authors: marchio a. J Gen Virol. 1998 Mar;79 ( Pt 3):591-600. doi: 10.1099/0022-1317-79-3-591. J Gen Virol. 1998. PMID: 9519839
In both cases, integrated viral sequences were characterized by a duplicated-inverted configuration involving the flanking cellular sequences, a pattern consistently found in many amplicons isolated from mammalian cells. ...The cis-activating potential of the integr …
In both cases, integrated viral sequences were characterized by a duplicated-inverted configuration involving the flanking cellular s …
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