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Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis.
Fernández S, Wasowski C, Paladini AC, Marder M. Fernández S, et al. Among authors: marder m. Pharmacol Biochem Behav. 2004 Feb;77(2):399-404. doi: 10.1016/j.pbb.2003.12.003. Pharmacol Biochem Behav. 2004. PMID: 14751470
[Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii].
Giraldo SE, Rincón J, Puebla P, Marder M, Wasowski C, Vergel N, Guerrero MF. Giraldo SE, et al. Among authors: marder m. Biomedica. 2010 Apr-Jun;30(2):245-50. Biomedica. 2010. PMID: 20890571 Spanish.
N,N'-dicyclohexylsulfamide and N,N'-diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABA(A) receptor and anxiolytic activity in mice.
Wasowski C, Gavernet L, Barrios IA, Villalba ML, Pastore V, Samaja G, Enrique A, Bruno-Blanch LE, Marder M. Wasowski C, et al. Among authors: marder m. Biochem Pharmacol. 2012 Jan 15;83(2):253-9. doi: 10.1016/j.bcp.2011.10.015. Epub 2011 Oct 29. Biochem Pharmacol. 2012. PMID: 22056620
Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines.
Loscalzo LM, Wasowski C, Paladini AC, Marder M. Loscalzo LM, et al. Among authors: marder m. Eur J Pharmacol. 2008 Feb 12;580(3):306-13. doi: 10.1016/j.ejphar.2007.11.011. Epub 2007 Nov 13. Eur J Pharmacol. 2008. PMID: 18048026
N-propyl-2,2-diphenyl-2-hydroxyacetamide, a novel α-hydroxyamide with anticonvulsant, anxiolytic and antidepressant-like effects that inhibits voltage-gated sodium channels.
Pastore V, Wasowski C, Martin P, Enrique A, Higgs J, Bruno-Blanch LE, Milesi V, Marder M. Pastore V, et al. Among authors: marder m. Eur J Pharmacol. 2018 Jan 15;819:270-280. doi: 10.1016/j.ejphar.2017.11.048. Epub 2017 Dec 5. Eur J Pharmacol. 2018. PMID: 29217174
Chronic intraperitoneal and oral treatments with hesperidin induce central nervous system effects in mice.
Wasowski C, Loscalzo LM, Higgs J, Marder M. Wasowski C, et al. Among authors: marder m. Phytother Res. 2012 Feb;26(2):308-12. doi: 10.1002/ptr.3560. Epub 2011 Jun 30. Phytother Res. 2012. PMID: 21717517
Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice.
Martínez MC, Fernandez SP, Loscalzo LM, Wasowski C, Paladini AC, Marder M, Medina JH, Viola H. Martínez MC, et al. Among authors: marder m. Pharmacol Biochem Behav. 2009 Apr;92(2):291-6. doi: 10.1016/j.pbb.2008.12.016. Epub 2008 Dec 31. Pharmacol Biochem Behav. 2009. PMID: 19159642
Neuroactive flavonoid glycosides from Tilia petiolaris DC. extracts.
Loscalzo LM, Wasowski C, Marder M. Loscalzo LM, et al. Among authors: marder m. Phytother Res. 2009 Oct;23(10):1453-7. doi: 10.1002/ptr.2800. Phytother Res. 2009. PMID: 19288528
Flavonoids as GABAA receptor ligands: the whole story?
Wasowski C, Marder M. Wasowski C, et al. Among authors: marder m. J Exp Pharmacol. 2012 Feb 23;4:9-24. doi: 10.2147/JEP.S23105. eCollection 2012. J Exp Pharmacol. 2012. PMID: 27186113 Free PMC article. Review.
Novel sulfamides and sulfamates derived from amino esters: Synthetic studies and anticonvulsant activity.
Villalba ML, Enrique AV, Higgs J, Castaño RA, Goicoechea S, Taborda FD, Gavernet L, Lick ID, Marder M, Bruno Blanch LE. Villalba ML, et al. Among authors: marder m. Eur J Pharmacol. 2016 Mar 5;774:55-63. doi: 10.1016/j.ejphar.2016.02.001. Epub 2016 Feb 2. Eur J Pharmacol. 2016. PMID: 26849942
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