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Cancer Metabolism: A Modeling Perspective.
Ghaffari P, Mardinoglu A, Nielsen J. Ghaffari P, et al. Among authors: mardinoglu a. Front Physiol. 2015 Dec 16;6:382. doi: 10.3389/fphys.2015.00382. eCollection 2015. Front Physiol. 2015. PMID: 26733270 Free PMC article. Review.
Also recent progresses in our understanding of carcinogenesis have revealed that cancer is a complex disease and cannot be understood through simple investigation of genetic mutations of cancerous cells. ...Here, we review cancer-associated reprogramming of metabolism and …
Also recent progresses in our understanding of carcinogenesis have revealed that cancer is a complex disease and cannot be understood …
Systems medicine and metabolic modelling.
Mardinoglu A, Nielsen J. Mardinoglu A, et al. J Intern Med. 2012 Feb;271(2):142-54. doi: 10.1111/j.1365-2796.2011.02493.x. J Intern Med. 2012. PMID: 22142312 Review.
Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT.
Agren R, Bordel S, Mardinoglu A, Pornputtapong N, Nookaew I, Nielsen J. Agren R, et al. Among authors: mardinoglu a. PLoS Comput Biol. 2012;8(5):e1002518. doi: 10.1371/journal.pcbi.1002518. Epub 2012 May 17. PLoS Comput Biol. 2012. PMID: 22615553 Free PMC article.
This opens for a new approach in health care, which is both personalized and based on system-level analysis. Genome-scale metabolic networks provide a mechanistic description of the relationships between different genes, which is valuable for the analysis and interp …
This opens for a new approach in health care, which is both personalized and based on system-level analysis. Genome-scale metabolic n …
Integration of clinical data with a genome-scale metabolic model of the human adipocyte.
Mardinoglu A, Agren R, Kampf C, Asplund A, Nookaew I, Jacobson P, Walley AJ, Froguel P, Carlsson LM, Uhlen M, Nielsen J. Mardinoglu A, et al. Mol Syst Biol. 2013;9:649. doi: 10.1038/msb.2013.5. Mol Syst Biol. 2013. PMID: 23511207 Free PMC article.
This information was used to reconstruct a comprehensive and functional genome-scale metabolic model of adipocyte metabolism. The resulting metabolic model, iAdipocytes1809, enables mechanistic insights into adipocyte metabolism on a genome-wide level, and can serve …
This information was used to reconstruct a comprehensive and functional genome-scale metabolic model of adipocyte metabolism. The res …
Genome-scale modeling of human metabolism - a systems biology approach.
Mardinoglu A, Gatto F, Nielsen J. Mardinoglu A, et al. Biotechnol J. 2013 Sep;8(9):985-96. doi: 10.1002/biot.201200275. Epub 2013 Apr 24. Biotechnol J. 2013. PMID: 23613448 Review.
Genome-scale metabolic models (GEMs) have been employed for studying human metabolism in a systematic manner, as well as for understanding complex human diseases. ...Finally, recent advancements in genome-scale modeling and the future challenge of developing a model …
Genome-scale metabolic models (GEMs) have been employed for studying human metabolism in a systematic manner, as well as for understa …
Understanding the interactions between bacteria in the human gut through metabolic modeling.
Shoaie S, Karlsson F, Mardinoglu A, Nookaew I, Bordel S, Nielsen J. Shoaie S, et al. Among authors: mardinoglu a. Sci Rep. 2013;3:2532. doi: 10.1038/srep02532. Sci Rep. 2013. PMID: 23982459 Free PMC article.
The human gut microbiome plays an influential role in maintaining human health, and it is a potential target for prevention and treatment of disease. ...Furthermore, we used our GEMs for analyzing the contribution of each species to the overall metabolism of the gut microb …
The human gut microbiome plays an influential role in maintaining human health, and it is a potential target for prevention and treat …
Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling.
Agren R, Mardinoglu A, Asplund A, Kampf C, Uhlen M, Nielsen J. Agren R, et al. Among authors: mardinoglu a. Mol Syst Biol. 2014 Mar 19;10(3):721. doi: 10.1002/msb.145122. Mol Syst Biol. 2014. PMID: 24646661 Free PMC article.
Genome-scale metabolic models (GEMs) have proven useful as scaffolds for the integration of omics data for understanding the genotype-phenotype relationship in a mechanistic manner. ...We used this information to reconstruct personalized GEMs for six HCC patients based on …
Genome-scale metabolic models (GEMs) have proven useful as scaffolds for the integration of omics data for understanding the genotype-phenot …
New paradigms for metabolic modeling of human cells.
Mardinoglu A, Nielsen J. Mardinoglu A, et al. Curr Opin Biotechnol. 2015 Aug;34:91-7. doi: 10.1016/j.copbio.2014.12.013. Epub 2015 Jan 2. Curr Opin Biotechnol. 2015. PMID: 25559199 Review.
GEnome-scale metabolic Models (GEMs) have enabled studying global metabolic reprogramming in connection with disease development in a systematic manner. ...
GEnome-scale metabolic Models (GEMs) have enabled studying global metabolic reprogramming in connection with disease development in a
Proteomics. Tissue-based map of the human proteome.
Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F. Uhlén M, et al. Among authors: mardinoglu a. Science. 2015 Jan 23;347(6220):1260419. doi: 10.1126/science.1260419. Science. 2015. PMID: 25613900
Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down …
Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics …
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