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Predicting growth of the healthy infant using a genome scale metabolic model.
Nilsson A, Mardinoglu A, Nielsen J. Nilsson A, et al. NPJ Syst Biol Appl. 2017 Jan 31;3:3. doi: 10.1038/s41540-017-0004-5. eCollection 2017. NPJ Syst Biol Appl. 2017. PMID: 28649430 Free PMC article.
We used a human genome scale metabolic model to simulate the mechanisms of growth and integrate data about breast-milk intake and composition with the infant's biomass and energy expenditure of major organs. ...The model and simulation method were integrated to a pl …
We used a human genome scale metabolic model to simulate the mechanisms of growth and integrate data about breast-milk intake and com …
An atlas of the protein-coding genes in the human, pig, and mouse brain.
Sjöstedt E, Zhong W, Fagerberg L, Karlsson M, Mitsios N, Adori C, Oksvold P, Edfors F, Limiszewska A, Hikmet F, Huang J, Du Y, Lin L, Dong Z, Yang L, Liu X, Jiang H, Xu X, Wang J, Yang H, Bolund L, Mardinoglu A, Zhang C, von Feilitzen K, Lindskog C, Pontén F, Luo Y, Hökfelt T, Uhlén M, Mulder J. Sjöstedt E, et al. Science. 2020 Mar 6;367(6482):eaay5947. doi: 10.1126/science.aay5947. Science. 2020. PMID: 32139519
To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. ...
To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissectio …
Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation.
Pagoni A, Marinelli L, Di Stefano A, Ciulla M, Turkez H, Mardinoglu A, Vassiliou S, Cacciatore I. Pagoni A, et al. Eur J Med Chem. 2020 Jan 15;186:111880. doi: 10.1016/j.ejmech.2019.111880. Epub 2019 Nov 12. Eur J Med Chem. 2020. PMID: 31753513
To date, drugs that hit a single target are inadequate for the treatment of neurodegenerative diseases, such as Alzheimer's or Parkinson's diseases. The development of multitarget ligands, able to interact with the different pathways involved in the progession of these dis …
To date, drugs that hit a single target are inadequate for the treatment of neurodegenerative diseases, such as Alzheimer's or Parkin …
Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D.
Sayitoglu EC, Georgoudaki AM, Chrobok M, Ozkazanc D, Josey BJ, Arif M, Kusser K, Hartman M, Chinn TM, Potens R, Pamukcu C, Krueger R, Zhang C, Mardinoglu A, Alici E, Temple HT, Sutlu T, Duru AD. Sayitoglu EC, et al. Front Immunol. 2020 Jan 28;11:40. doi: 10.3389/fimmu.2020.00040. eCollection 2020. Front Immunol. 2020. PMID: 32082316 Free PMC article.
We also applied a functional screening approach to identify relevant NK cell receptor/ligand interactions that induce efficient anti-tumor responses using a panel NK-92 cell lines GM to over-express 12 different activating receptors. ...In conclusion, DNAM-1 or NKG2 …
We also applied a functional screening approach to identify relevant NK cell receptor/ligand interactions that induce efficient anti- …
An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models.
Choi MJ, Jung SB, Lee SE, Kang SG, Lee JH, Ryu MJ, Chung HK, Chang JY, Kim YK, Hong HJ, Kim H, Kim HJ, Lee CH, Mardinoglu A, Yi HS, Shong M. Choi MJ, et al. Diabetologia. 2020 Apr;63(4):837-852. doi: 10.1007/s00125-019-05082-7. Epub 2020 Jan 10. Diabetologia. 2020. PMID: 31925461
AdKO mice fed a normal chow or high-fat diet were evaluated for glucose homeostasis, weight gain and energy expenditure (EE). ...
AdKO mice fed a normal chow or high-fat diet were evaluated for glucose homeostasis, weight gain and energy expenditure (EE). ...
Systems medicine and metabolic modelling.
Mardinoglu A, Nielsen J. Mardinoglu A, et al. J Intern Med. 2012 Feb;271(2):142-54. doi: 10.1111/j.1365-2796.2011.02493.x. J Intern Med. 2012. PMID: 22142312 Review.
Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT.
Agren R, Bordel S, Mardinoglu A, Pornputtapong N, Nookaew I, Nielsen J. Agren R, et al. PLoS Comput Biol. 2012;8(5):e1002518. doi: 10.1371/journal.pcbi.1002518. Epub 2012 May 17. PLoS Comput Biol. 2012. PMID: 22615553 Free PMC article.
This opens for a new approach in health care, which is both personalized and based on system-level analysis. Genome-scale metabolic networks provide a mechanistic description of the relationships between different genes, which is valuable for the analysis and interp …
This opens for a new approach in health care, which is both personalized and based on system-level analysis. Genome-scale metabolic n …
Integration of clinical data with a genome-scale metabolic model of the human adipocyte.
Mardinoglu A, Agren R, Kampf C, Asplund A, Nookaew I, Jacobson P, Walley AJ, Froguel P, Carlsson LM, Uhlen M, Nielsen J. Mardinoglu A, et al. Mol Syst Biol. 2013;9:649. doi: 10.1038/msb.2013.5. Mol Syst Biol. 2013. PMID: 23511207 Free PMC article.
This information was used to reconstruct a comprehensive and functional genome-scale metabolic model of adipocyte metabolism. The resulting metabolic model, iAdipocytes1809, enables mechanistic insights into adipocyte metabolism on a genome-wide level, and can serve …
This information was used to reconstruct a comprehensive and functional genome-scale metabolic model of adipocyte metabolism. The res …
Genome-scale modeling of human metabolism - a systems biology approach.
Mardinoglu A, Gatto F, Nielsen J. Mardinoglu A, et al. Biotechnol J. 2013 Sep;8(9):985-96. doi: 10.1002/biot.201200275. Epub 2013 Apr 24. Biotechnol J. 2013. PMID: 23613448 Review.
Genome-scale metabolic models (GEMs) have been employed for studying human metabolism in a systematic manner, as well as for understanding complex human diseases. ...Finally, recent advancements in genome-scale modeling and the future challenge of developing a model …
Genome-scale metabolic models (GEMs) have been employed for studying human metabolism in a systematic manner, as well as for understa …
Understanding the interactions between bacteria in the human gut through metabolic modeling.
Shoaie S, Karlsson F, Mardinoglu A, Nookaew I, Bordel S, Nielsen J. Shoaie S, et al. Sci Rep. 2013;3:2532. doi: 10.1038/srep02532. Sci Rep. 2013. PMID: 23982459 Free PMC article.
The human gut microbiome plays an influential role in maintaining human health, and it is a potential target for prevention and treatment of disease. ...Furthermore, we used our GEMs for analyzing the contribution of each species to the overall metabolism of the gut microb …
The human gut microbiome plays an influential role in maintaining human health, and it is a potential target for prevention and treat …
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