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Major thermogenic defect associated with insulin resistance in brown adipose tissue of obese diabetic SHR/N-cp rats.
Marette A, Deshaies Y, Collet AJ, Tulp O, Bukowiecki LJ. Marette A, et al. Am J Physiol. 1991 Aug;261(2 Pt 1):E204-13. doi: 10.1152/ajpendo.1991.261.2.E204. Am J Physiol. 1991. PMID: 1651655
In the same cells, there was a similar decrease in the respiratory response to dibutyryl adenosine 3',5'-cyclic monophosphate, indicating the presence of a major postreceptor defect. ...It is suggested that insulin resistance and/or diabetes in SHR/N-cp rats lead to …
In the same cells, there was a similar decrease in the respiratory response to dibutyryl adenosine 3',5'-cyclic monophosphate, indica …
Mechanism linking insulin resistance to defective thermogenesis in brown adipose tissue of obese diabetic SHR/N-cp rats.
Marette A, Tulp OL, Bukowiecki LJ. Marette A, et al. Int J Obes. 1991 Dec;15(12):823-31. Int J Obes. 1991. PMID: 1665483
In the same cells, there was a similar decrease in the respiratory effects of dibutyryl cAMP (DBcAMP), revealing the presence of a major post-receptor defect. Remarkably, total cytochrome oxidase activity (an index of cell mitochondrial content) was also decreased b …
In the same cells, there was a similar decrease in the respiratory effects of dibutyryl cAMP (DBcAMP), revealing the presence of a
Defective metabolic effects of norepinephrine and insulin in obese Zucker rat brown adipose tissue.
Marette A, Géloën A, Collet A, Bukowiecki LJ. Marette A, et al. Am J Physiol. 1990 Feb;258(2 Pt 1):E320-8. doi: 10.1152/ajpendo.1990.258.2.E320. Am J Physiol. 1990. PMID: 2154935
Total BAT protein content and cytochrome oxidase activity were similar in both phenotypes, suggesting that obese rats have a normal mitochondrial content. ...Addition of dibutyryl adenosine 3',5'-cyclic monophosphate to respiring obese rat brown adipocytes restored to norm …
Total BAT protein content and cytochrome oxidase activity were similar in both phenotypes, suggesting that obese rats have a normal m …
Mechanism of norepinephrine stimulation of glucose transport in isolated rat brown adipocytes.
Marette A, Bukowiecki LJ. Marette A, et al. Int J Obes. 1990 Oct;14(10):857-67. Int J Obes. 1990. PMID: 2176649
Considering that cold exposure increases the plasma levels of norepinephrine and lipolytic hormones, but decreases the levels of insulin, we have examined the effects of these agents on glucose transport in isolated rat brown adipocytes using D-[U-14C]glucose as a tracer. …
Considering that cold exposure increases the plasma levels of norepinephrine and lipolytic hormones, but decreases the levels of insulin, we …
Marked depletion of GLUT4 glucose transporters in transverse tubules of skeletal muscle from streptozotocin-induced diabetic rats.
Dombrowski L, Marette A. Dombrowski L, et al. FEBS Lett. 1995 Oct 23;374(1):43-7. doi: 10.1016/0014-5793(95)01071-l. FEBS Lett. 1995. PMID: 7589509
The principal goal of the present study was to determine the subcellular content of GLUT4 in diabetic rat muscle, and to test the hypothesis that a reduced abundance of the transporter protein in transverse tubules is responsible for impaired glucose utilization in that ti …
The principal goal of the present study was to determine the subcellular content of GLUT4 in diabetic rat muscle, and to test the hypothesis …
Regional variation in adipose tissue metabolism of severely obese premenopausal women.
Mauriège P, Marette A, Atgié C, Bouchard C, Thériault G, Bukowiecki LK, Marceau P, Biron S, Nadeau A, Després JP. Mauriège P, et al. J Lipid Res. 1995 Apr;36(4):672-84. J Lipid Res. 1995. PMID: 7616115

Although epinephrine initiated a similar biphasic profile of response in all cell types, the catecholamine promoted a weaker inhibition of lipolysis in omental adipocytes than in subcutaneous abdominal adipose cells (P < 0.05). ...Finally, a lower beta-adr

Although epinephrine initiated a similar biphasic profile of response in all cell types, the catecholamine promoted a weaker i …
Relation of components of insulin resistance syndrome to coronary disease risk.
Després JP, Marette A. Després JP, et al. Curr Opin Lipidol. 1994 Aug;5(4):274-89. doi: 10.1097/00041433-199408000-00006. Curr Opin Lipidol. 1994. PMID: 7981959 Review.
Insulin resistance, which is a prevalent condition, has been associated with a cluster of metabolic disturbances that increase the risk of non-insulin-dependent diabetes mellitus and cardiovascular diseases. ...
Insulin resistance, which is a prevalent condition, has been associated with a cluster of metabolic disturbances that increase …
Norepinephrine- and insulin-resistant glucose transport in brown adipocytes from diabetic SHR/N-cp rats.
Marette A, Mauriège P, Després JP, Tulp OL, Bukowiecki LJ. Marette A, et al. Am J Physiol. 1993 Sep;265(3 Pt 2):R577-83. doi: 10.1152/ajpregu.1993.265.3.R577. Am J Physiol. 1993. PMID: 8214149
These results indicate that 1) major metabolic defects are present in brown adipose tissue (BAT) of O-SHR but not of O-LA, although these two strains are homozygous for the cp allele, 2) postreceptor defects are predominantly involved in O-SHR adipocyte refractoriness to norepine …
These results indicate that 1) major metabolic defects are present in brown adipose tissue (BAT) of O-SHR but not of O-LA, although these tw …
Specific decrease of mitochondrial thermogenic capacity in brown adipose tissue of obese SHR/N-cp rats.
Atgié C, Marette A, Desautels M, Tulp O, Bukowiecki LJ. Atgié C, et al. Am J Physiol. 1993 Dec;265(6 Pt 1):C1674-80. doi: 10.1152/ajpcell.1993.265.6.C1674. Am J Physiol. 1993. PMID: 8279528
The metabolic properties of brown adipose tissue (BAT), liver, and skeletal muscles were compared in lean and obese diabetic SHR/N-cp rats (a new model of type II diabetes) to test whether the severe insulin resistance of obese animals is specifically associated with a
The metabolic properties of brown adipose tissue (BAT), liver, and skeletal muscles were compared in lean and obese diabetic SHR/N-cp rats ( …
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