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Page 1
Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice.
Green CL, Trautman ME, Chaiyakul K, Jain R, Alam YH, Babygirija R, Pak HH, Sonsalla MM, Calubag MF, Yeh CY, Bleicher A, Novak G, Liu TT, Newman S, Ricke WA, Matkowskyj KA, Ong IM, Jang C, Simcox J, Lamming DW. Green CL, et al. Among authors: calubag mf. Cell Metab. 2023 Nov 7;35(11):1976-1995.e6. doi: 10.1016/j.cmet.2023.10.005. Cell Metab. 2023. PMID: 37939658 Free PMC article.
Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging.
Yeh CY, Chini LCS, Davidson JW, Garcia GG, Gallagher MS, Freichels IT, Calubag MF, Rodgers AC, Green CL, Babygirija R, Sonsalla MM, Pak HH, Trautman ME, Hacker TA, Miller RA, Simcox JA, Lamming DW. Yeh CY, et al. Among authors: calubag mf. Nat Aging. 2024 Dec;4(12):1760-1771. doi: 10.1038/s43587-024-00744-7. Epub 2024 Nov 27. Nat Aging. 2024. PMID: 39604703 Free PMC article.
Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction.
Yeh CY, Borgelt AL, Vogt BJ, Clark AA, Wong TT, Grunow I, Sonsalla MM, Babygirija R, Liu Y, Trautman ME, Calubag MF, Knopf BA, Xiao F, Lamming DW. Yeh CY, et al. Among authors: calubag mf. Aging Cell. 2026 Jan;25(1):e70318. doi: 10.1111/acel.70318. Epub 2025 Dec 10. Aging Cell. 2026. PMID: 41369866 Free PMC article.
Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease.
Babygirija R, Han JH, Sonsalla MM, Matoska R, Calubag MF, Green CL, Tobon A, Yeh CY, Vertein D, Schlorf S, Illiano J, Liu Y, Grunow I, Rigby MJ, Puglielli L, Harris DA, Denu JM, Lamming DW. Babygirija R, et al. Among authors: calubag mf. Nat Commun. 2025 Aug 4;16(1):7147. doi: 10.1038/s41467-025-62416-3. Nat Commun. 2025. PMID: 40759886 Free PMC article.
Ketogenesis is dispensable for the metabolic adaptations to caloric restriction.
Yeh CY, Borgelt L, Vogt BJ, Clark AA, Wong TT, Grunow I, Sonsalla MM, Babygirija R, Liu Y, Trautman ME, Calubag MF, Knopf BA, Xiao F, Lamming DW. Yeh CY, et al. Among authors: calubag mf. bioRxiv [Preprint]. 2025 Jun 1:2025.05.29.656153. doi: 10.1101/2025.05.29.656153. bioRxiv. 2025. Update in: Aging Cell. 2026 Jan;25(1):e70318. doi: 10.1111/acel.70318. PMID: 40501543 Free PMC article. Updated. Preprint.
Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice.
Calubag MF, Ademi I, Green CL, Jayarathne HSM, Manchanayake DNH, Le SM, Lialios P, Breuer LE, Yakar S, Babygirija R, Sonsalla MM, Grunow I, Yeh CY, Liu Y, Knopf BA, Ricke WA, Liu TT, Sadagurski M, Lamming DW. Calubag MF, et al. bioRxiv [Preprint]. 2025 Sep 4:2025.08.31.673254. doi: 10.1101/2025.08.31.673254. bioRxiv. 2025. PMID: 40950235 Free PMC article. Preprint.
Restriction of Individual Branched-Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice.
Babygirija R, Green CL, Sonsalla MM, Le IMF, Xiao F, Yandell S, Calubag MF, Trautman ME, Tobon A, Matoska R, Yeh CY, Opara CI, Grunow I, Vertein D, Schlorf S, Knopf BA, Rigby MJ, Harris DA, Keller MP, Attie AD, Puglielli L, Jang C, Lamming DW. Babygirija R, et al. Among authors: calubag mf. Adv Sci (Weinh). 2026 May;13(30):e15220. doi: 10.1002/advs.202515220. Epub 2026 Mar 12. Adv Sci (Weinh). 2026. PMID: 41817439 Free PMC article.
21 results