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Targeting phosphoinositide 3-kinase: moving towards therapy.
Marone R, Cmiljanovic V, Giese B, Wymann MP. Marone R, et al. Biochim Biophys Acta. 2008 Jan;1784(1):159-85. doi: 10.1016/j.bbapap.2007.10.003. Epub 2007 Oct 12. Biochim Biophys Acta. 2008. PMID: 17997386 Review.
Memo mediates ErbB2-driven cell motility.
Marone R, Hess D, Dankort D, Muller WJ, Hynes NE, Badache A. Marone R, et al. Nat Cell Biol. 2004 Jun;6(6):515-22. doi: 10.1038/ncb1134. Epub 2004 May 23. Nat Cell Biol. 2004. PMID: 15156151
Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.
Ciraolo E, Morello F, Hobbs RM, Wolf F, Marone R, Iezzi M, Lu X, Mengozzi G, Altruda F, Sorba G, Guan K, Pandolfi PP, Wymann MP, Hirsch E. Ciraolo E, et al. Mol Biol Cell. 2010 Mar 1;21(5):704-11. doi: 10.1091/mbc.e09-08-0744. Epub 2010 Jan 6. Mol Biol Cell. 2010. PMID: 20053680 Free PMC article.
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.
Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastrù W, Martin EL, Silengo L, Altruda F, Turco E, Lanzetti L, Musiani P, Rückle T, Rommel C, Backer JM, Forni G, Wymann MP, Hirsch E. Ciraolo E, et al. Sci Signal. 2008 Sep 9;1(36):ra3. doi: 10.1126/scisignal.1161577. Sci Signal. 2008. PMID: 18780892 Free PMC article.
PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.
Becattini B, Marone R, Zani F, Arsenijevic D, Seydoux J, Montani JP, Dulloo AG, Thorens B, Preitner F, Wymann MP, Solinas G. Becattini B, et al. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):E854-63. doi: 10.1073/pnas.1106698108. Epub 2011 Sep 26. Proc Natl Acad Sci U S A. 2011. PMID: 21949398 Free PMC article.
Targeting PI3K in neuroblastoma.
Spitzenberg V, König C, Ulm S, Marone R, Röpke L, Müller JP, Grün M, Bauer R, Rubio I, Wymann MP, Voigt A, Wetzker R. Spitzenberg V, et al. J Cancer Res Clin Oncol. 2010 Dec;136(12):1881-90. doi: 10.1007/s00432-010-0847-2. Epub 2010 Mar 12. J Cancer Res Clin Oncol. 2010. PMID: 20224967
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