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Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis.
Verzijl N, DeGroot J, Ben ZC, Brau-Benjamin O, Maroudas A, Bank RA, Mizrahi J, Schalkwijk CG, Thorpe SR, Baynes JW, Bijlsma JW, Lafeber FP, TeKoppele JM. Verzijl N, et al. Among authors: maroudas a. Arthritis Rheum. 2002 Jan;46(1):114-23. doi: 10.1002/1529-0131(200201)46:1<114::AID-ART10025>3.0.CO;2-P. Arthritis Rheum. 2002. PMID: 11822407 Free article.
Age-related accumulation of pentosidine in aggrecan and collagen from normal and degenerate human intervertebral discs.
Sivan SS, Tsitron E, Wachtel E, Roughley P, Sakkee N, van der Ham F, Degroot J, Maroudas A. Sivan SS, et al. Among authors: maroudas a. Biochem J. 2006 Oct 1;399(1):29-35. doi: 10.1042/BJ20060579. Biochem J. 2006. PMID: 16787390 Free PMC article.
We found that, after maturity, pentosidine accumulates with age. Over the age range studied, a linear 6-fold increase was observed in pentosidine accumulation for A1 and collagen with respective rates of 0.12 and 0.66 nmol x (g of protein)(-1) x year(-1). Using previously …
We found that, after maturity, pentosidine accumulates with age. Over the age range studied, a linear 6-fold increase was observed in …
82 results