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CLEC-2 is required for development and maintenance of lymph nodes.
Bénézech C, Nayar S, Finney BA, Withers DR, Lowe K, Desanti GE, Marriott CL, Watson SP, Caamaño JH, Buckley CD, Barone F. Bénézech C, et al. Among authors: marriott cl. Blood. 2014 May 15;123(20):3200-7. doi: 10.1182/blood-2013-03-489286. Epub 2014 Feb 14. Blood. 2014. PMID: 24532804 Free PMC article.
Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells.
Withers DR, Hepworth MR, Wang X, Mackley EC, Halford EE, Dutton EE, Marriott CL, Brucklacher-Waldert V, Veldhoen M, Kelsen J, Baldassano RN, Sonnenberg GF. Withers DR, et al. Among authors: marriott cl. Nat Med. 2016 Mar;22(3):319-23. doi: 10.1038/nm.4046. Epub 2016 Feb 15. Nat Med. 2016. PMID: 26878233 Free PMC article.
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