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Optimization of the potency and pharmacokinetic properties of a macrocyclic ghrelin receptor agonist (Part I): Development of ulimorelin (TZP-101) from hit to clinic.
Hoveyda HR, Marsault E, Gagnon R, Mathieu AP, Vézina M, Landry A, Wang Z, Benakli K, Beaubien S, Saint-Louis C, Brassard M, Pinault JF, Ouellet L, Bhat S, Ramaseshan M, Peng X, Foucher L, Beauchemin S, Bhérer P, Veber DF, Peterson ML, Fraser GL. Hoveyda HR, et al. Among authors: marsault e. J Med Chem. 2011 Dec 22;54(24):8305-20. doi: 10.1021/jm2007062. Epub 2011 Nov 22. J Med Chem. 2011. PMID: 22106937
Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties.
Demeule M, Beaudet N, Régina A, Besserer-Offroy É, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault É, Leduc R, Lachowicz JE, Gonias SL, Castaigne JP, Sarret P. Demeule M, et al. Among authors: marsault e. J Clin Invest. 2014 Mar;124(3):1199-213. doi: 10.1172/JCI70647. Epub 2014 Feb 17. J Clin Invest. 2014. PMID: 24531547 Free PMC article.
Design and synthesis of potent, selective inhibitors of matriptase.
Colombo E, Désilets A, Duchêne D, Chagnon F, Najmanovich R, Leduc R, Marsault E. Colombo E, et al. Among authors: marsault e. ACS Med Chem Lett. 2012 Apr 11;3(7):530-4. doi: 10.1021/ml3000534. eCollection 2012 Jul 12. ACS Med Chem Lett. 2012. PMID: 24900505 Free PMC article.
77 results