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An alternative splice process renders the MLL protein either into a transcriptional activator or repressor.
Rössler T, Marschalek R. Rössler T, et al. Among authors: marschalek r. Pharmazie. 2013 Jul;68(7):601-7. doi: 10.1055/s-0033-1343653. Pharmazie. 2013. PMID: 23923644
The AF4-MLL fusion transiently augments multilineage hematopoietic engraftment but is not sufficient to initiate leukemia in cord blood CD34+ cells.
Prieto C, Marschalek R, Kühn A, Bursen A, Bueno C, Menéndez P. Prieto C, et al. Among authors: marschalek r. Oncotarget. 2017 Jul 26;8(47):81936-81941. doi: 10.18632/oncotarget.19567. eCollection 2017 Oct 10. Oncotarget. 2017. PMID: 29137234 Free PMC article.
A case of pediatric acute myeloid leukemia with t(11;16)(q23;q24) leading to a novel KMT2A-USP10 fusion gene.
Zerkalenkova E, Lebedeva S, Kazakova A, Baryshev P, Meyer C, Marschalek R, Novichkova G, Maschan M, Maschan A, Olshanskaya Y. Zerkalenkova E, et al. Among authors: marschalek r. Genes Chromosomes Cancer. 2018 Oct;57(10):522-524. doi: 10.1002/gcc.22646. Epub 2018 Aug 14. Genes Chromosomes Cancer. 2018. PMID: 30107050
TGFβ/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation.
Saul MJ, Groher F, Hegewald AB, Müller-McNicoll M, Marschalek R, Suess B, Steinhilber D. Saul MJ, et al. Among authors: marschalek r. Prostaglandins Other Lipid Mediat. 2017 Nov;133:60-67. doi: 10.1016/j.prostaglandins.2017.07.006. Epub 2017 Aug 11. Prostaglandins Other Lipid Mediat. 2017. PMID: 28803964
AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3.
Ahmad K, Scholz B, Capelo R, Schweighöfer I, Kahnt AS, Marschalek R, Steinhilber D. Ahmad K, et al. Among authors: marschalek r. Oncotarget. 2015 Sep 22;6(28):25784-800. doi: 10.18632/oncotarget.4703. Oncotarget. 2015. PMID: 26329759 Free PMC article.
Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4-MLL Fusion Protein.
Sabiani S, Geppert T, Engelbrecht C, Kowarz E, Schneider G, Marschalek R. Sabiani S, et al. Among authors: marschalek r. EBioMedicine. 2015 Apr 16;2(5):386-95. doi: 10.1016/j.ebiom.2015.04.009. eCollection 2015 May. EBioMedicine. 2015. PMID: 26137584 Free PMC article.
Refinement of IKZF1 recombination hotspots in pediatric BCP-ALL patients.
Meyer C, Zur Stadt U, Escherich G, Hofmann J, Binato R, Barbosa TC, Emerenciano M, Pombo-de-Oliveira MS, Horstmann M, Marschalek R. Meyer C, et al. Among authors: marschalek r. Am J Blood Res. 2013 May 5;3(2):165-73. Print 2013. Am J Blood Res. 2013. PMID: 23675566 Free PMC article.
Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells.
Wegner MS, Wanger RA, Oertel S, Brachtendorf S, Hartmann D, Schiffmann S, Marschalek R, Schreiber Y, Ferreirós N, Geisslinger G, Grösch S. Wegner MS, et al. Among authors: marschalek r. Biochem Pharmacol. 2014 Dec 15;92(4):577-89. doi: 10.1016/j.bcp.2014.10.007. Epub 2014 Oct 22. Biochem Pharmacol. 2014. PMID: 25451689
Diagnostic tool for the identification of MLL rearrangements including unknown partner genes.
Meyer C, Schneider B, Reichel M, Angermueller S, Strehl S, Schnittger S, Schoch C, Jansen MW, van Dongen JJ, Pieters R, Haas OA, Dingermann T, Klingebiel T, Marschalek R. Meyer C, et al. Among authors: marschalek r. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):449-54. doi: 10.1073/pnas.0406994102. Epub 2004 Dec 30. Proc Natl Acad Sci U S A. 2005. PMID: 15626757 Free PMC article.
Epigenetics and blood disorders.
Scholz B, Marschalek R. Scholz B, et al. Among authors: marschalek r. Br J Haematol. 2012 Aug;158(3):307-22. doi: 10.1111/j.1365-2141.2012.09193.x. Epub 2012 Jun 20. Br J Haematol. 2012. PMID: 22712628 Review.
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