Paraoxonase-1 in female infertility: a possible role against oxidative stress-induced inflammation

Judit Marsillach; Miguel Angel Checa; Juan Pedro-Botet; Ramon Carreras; Jorge Joven; Jordi Camps

doi:10.1016/j.fertnstert.2009.11.043

Paraoxonase-1 in female infertility: a possible role against oxidative stress-induced inflammation

Fertil Steril. 2010 Aug;94(3):1132-4. doi: 10.1016/j.fertnstert.2009.11.043. Epub 2010 Jan 25.

Authors

Judit Marsillach¹, Miguel Angel Checa, Juan Pedro-Botet, Ramon Carreras, Jorge Joven, Jordi Camps

Affiliation

¹ Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Reus, Catalunya, Spain.

PMID: 20100610
DOI: 10.1016/j.fertnstert.2009.11.043

Abstract

In this observational, case-control study in infertile women, we observed elevated serum oxidative stress that was significantly correlated with an increase in serum paraoxonase-1 activity and without any evidence of a proinflammatory reaction. These results suggest a protective role of paraoxonase-1 against inflammation in this clinical setting.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aryldialkylphosphatase / blood*
Aryldialkylphosphatase / metabolism
Aryldialkylphosphatase / physiology*
C-Reactive Protein / analysis
C-Reactive Protein / metabolism
Case-Control Studies
Chemokine CCL2 / blood
Chemokine CCL2 / metabolism
Female
Humans
Infertility, Female / blood*
Infertility, Female / etiology
Infertility, Female / metabolism
Inflammation / blood
Inflammation / etiology*
Inflammation / metabolism
Inflammation / prevention & control*
Interleukin-6 / blood
Lipid Peroxides / blood
Oxidative Stress / physiology*
Polycystic Ovary Syndrome / blood
Polycystic Ovary Syndrome / metabolism
Young Adult

Substances

CCL2 protein, human
Chemokine CCL2
IL6 protein, human
Interleukin-6
Lipid Peroxides
C-Reactive Protein
Aryldialkylphosphatase
PON1 protein, human