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Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse.
Engebretsen KV, Waehre A, Bjørnstad JL, Skrbic B, Sjaastad I, Behmen D, Marstein HS, Yndestad A, Aukrust P, Christensen G, Tønnessen T. Engebretsen KV, et al. Among authors: marstein hs. J Appl Physiol (1985). 2013 Apr;114(8):988-97. doi: 10.1152/japplphysiol.00793.2012. Epub 2013 Feb 14. J Appl Physiol (1985). 2013. PMID: 23412898 Free article.
Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli.
Engebretsen KV, Lunde IG, Strand ME, Waehre A, Sjaastad I, Marstein HS, Skrbic B, Dahl CP, Askevold ET, Christensen G, Bjørnstad JL, Tønnessen T. Engebretsen KV, et al. Among authors: marstein hs. FEBS J. 2013 May;280(10):2382-98. doi: 10.1111/febs.12235. Epub 2013 Apr 2. FEBS J. 2013. PMID: 23480731 Free article.
The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload.
Mohammadzadeh N, Lunde IG, Andenæs K, Strand ME, Aronsen JM, Skrbic B, Marstein HS, Bandlien C, Nygård S, Gorham J, Sjaastad I, Chakravarti S, Christensen G, Engebretsen KVT, Tønnessen T. Mohammadzadeh N, et al. Among authors: marstein hs. Sci Rep. 2019 Jun 24;9(1):9206. doi: 10.1038/s41598-019-45651-9. Sci Rep. 2019. PMID: 31235849 Free PMC article.
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