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Page 1
Spatial architecture contributes to failure of bulk biomarker-guided neoadjuvant immunotherapy selection in bladder cancer: The DUTRENEO study.
Grande E, Sibai M, Grases D, Andrada E, Reig O, Escobosa M, Azueta A, Castellano D, Puente J, Martínez de Villarreal J, Font A, Alonso-Gordoa T, Benítez R, Moreno-Oya A, Álvarez-Maestro M, Burgos J, Climent MA, Domínguez M, Galván P, Galante I, García JF, Perez E, García Del Muro X, Guerrero-Ramos F, Marqués M, Maroto P, Paramio JM, Pinto A, Prat A, Malats N, Durán I, Porta-Pardo E, Real FX. Grande E, et al. Among authors: martinez de villarreal j. Cell Rep Med. 2026 Jun 23:102878. doi: 10.1016/j.xcrm.2026.102878. Online ahead of print. Cell Rep Med. 2026. PMID: 42335902 Free article.
Phase I trial of intravenous VCN-01 oncolytic adenovirus and durvalumab in patients with head and neck metastatic squamous cell carcinoma refractory to immunotherapy.
Jove M, Braña I, Oliva M, Hernando-Calvo A, Erasun C, Mato-Berciano A, Maliandi MV, Torres-Manjon S, Rojas LA, Connelly S, Bazan-Peregrino M, Moreno R, Martínez de Villarreal J, Real FX, Le C, Nuciforo P, Alemany R, Capellà G, Blasco C, Cascalló M, Mesía R. Jove M, et al. Among authors: martinez de villarreal j. Clin Cancer Res. 2026 Jun 8. doi: 10.1158/1078-0432.CCR-26-0601. Online ahead of print. Clin Cancer Res. 2026. PMID: 42257887
GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions.
Madriles F, de Andres MP, Chesnokov M, Martinez de Villarreal J, Alonso-Curbelo D, Del Pozo N, Iglesias M, Carrillo-de-Santa-Pau E, Iovanna J, Soriano F, Cuadrado A, Marques M, Muñoz J, Esposito I, Martinelli P, Lowe SW, Real FX. Madriles F, et al. Among authors: martinez de villarreal j. bioRxiv [Preprint]. 2026 May 26:2026.05.22.724502. doi: 10.64898/2026.05.22.724502. bioRxiv. 2026. PMID: 42244674 Free PMC article. Preprint.
STAG2 cohesin cooperates with DREAM to maintain quiescence and suppress tumourigenesis in the urothelium.
Ramal M, Lapi E, Kalisz M, Martínez de Villarreal J, Novillo-Font M, Marqués M, Zarzuela E, Isasa M, Graña-Castro O, Xu J, Cayuela A, Radvanyi F, Novell M, Martínez-Torrecuadrada JL, Barallobre MJ, Bernard-Pierrot I, Marti-Marimon M, Arbonés ML, Marti-Renom MA, Real FX. Ramal M, et al. Among authors: martinez de villarreal j. bioRxiv [Preprint]. 2025 Oct 13:2025.10.10.681713. doi: 10.1101/2025.10.10.681713. bioRxiv. 2025. PMID: 41279016 Free PMC article. Preprint.
A Common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice.
Bodas C, Felipe I, Chanez B, Lafarga M, Lopez de Maturana E, Martinez de Villarreal J, Del Pozo N, Malumbres M, Vargiu P, Cayuela A, Peset I, Connelly K, Hoskins J, Méndez R, Amundadottir L, Malats N, Ortega S, Real FX. Bodas C, et al. Among authors: martinez de villarreal j. Gut. 2025 Aug 7;74(9):1452-1466. doi: 10.1136/gutjnl-2024-333406. Gut. 2025. PMID: 40254337
The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity.
Sibai M, Cervilla S, Grases D, Musulen E, Lazcano R, Mo CK, Davalos V, Fortian A, Bernat A, Romeo M, Tokheim C, Barretina J, Lazar AJ, Ding L; DUTRENEO Study Investigators; Grande E, Real FX, Esteller M, Bailey MH, Porta-Pardo E. Sibai M, et al. Cell Rep. 2025 Feb 25;44(2):115229. doi: 10.1016/j.celrep.2024.115229. Epub 2025 Jan 24. Cell Rep. 2025. PMID: 39864059 Free article.
Characterisation of the tumour microenvironment and PD-L1 granularity reveals the prognostic value of cancer-associated myofibroblasts in non-invasive bladder cancer.
Cañizo CG, Guerrero-Ramos F, Perez Escavy M, Lodewijk I, Suárez-Cabrera C, Morales L, Nunes SP, Munera-Maravilla E, Rubio C, Sánchez R, Rodriguez-Izquierdo M, Martínez de Villarreal J, Real FX, Castellano D, Martín-Arriscado C, Lora Pablos D, Rodríguez Antolín A, Dueñas M, Paramio JM, Martínez VG. Cañizo CG, et al. Among authors: martinez de villarreal j. Oncoimmunology. 2025 Dec;14(1):2438291. doi: 10.1080/2162402X.2024.2438291. Epub 2024 Dec 19. Oncoimmunology. 2025. PMID: 39698899 Free PMC article.
A common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice.
Bodas C, Felipe I, Chanez B, Lafarga M, López de Maturana E, Martínez-de-Villarreal J, Del Pozo N, Malumbres M, Vargiu P, Cayuela A, Peset I, Connelly KE, Hoskins JW, Méndez R, Amundadottir LT, Malats N, Ortega S, Real FX. Bodas C, et al. Among authors: martinez de villarreal j. bioRxiv [Preprint]. 2024 Jul 24:2024.07.23.604778. doi: 10.1101/2024.07.23.604778. bioRxiv. 2024. Update in: Gut. 2025 Aug 7;74(9):1452-1466. doi: 10.1136/gutjnl-2024-333406. PMID: 39211105 Free PMC article. Updated. Preprint.
Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids.
Bustamante-Madrid P, Barbáchano A, Albandea-Rodríguez D, Rodríguez-Cobos J, Rodríguez-Salas N, Prieto I, Burgos A, Martínez de Villarreal J, Real FX, González-Sancho JM, Larriba MJ, Lafarga M, Muñoz A, Fernández-Barral A. Bustamante-Madrid P, et al. Among authors: martinez de villarreal j. Cell Death Dis. 2024 Apr 29;15(4):301. doi: 10.1038/s41419-024-06680-z. Cell Death Dis. 2024. PMID: 38684650 Free PMC article.
BPTF cooperates with MYCN and MYC to link neuroblastoma cell cycle control to epigenetic cellular states.
Felipe I, Martínez-de-Villarreal J, Patel K, Martínez-Torrecuadrada J, Grossmann LD, Roncador G, Cubells M, Farrell A, Kendsersky N, Sabroso-Lasa S, Sancho-Temiño L, Torres K, Martinez D, Perez JM, García F, Pogoriler J, Moreno L, Maris JM, Real FX. Felipe I, et al. Among authors: martinez de villarreal j. bioRxiv [Preprint]. 2024 Feb 12:2024.02.11.579816. doi: 10.1101/2024.02.11.579816. bioRxiv. 2024. PMID: 38405949 Free PMC article. Preprint.
18 results