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Neuroprotective Effects of Cannabidiol in Hypoxic Ischemic Insult. The Therapeutic Window in Newborn Mice.
Mohammed N, Ceprian M, Jimenez L, Pazos MR, Martínez-Orgado J. Mohammed N, et al. CNS Neurol Disord Drug Targets. 2017;16(1):102-108. doi: 10.2174/1871527315666160927110305. CNS Neurol Disord Drug Targets. 2017. PMID: 27686886
Neuroprotection by the cannabinoid agonist WIN-55212 in an in vivo newborn rat model of acute severe asphyxia.
Martínez-Orgado J, Fernández-Frutos B, González R, Romero E, Urigüen L, Romero J, Viveros MP. Martínez-Orgado J, et al. Brain Res Mol Brain Res. 2003 Jun 10;114(2):132-9. doi: 10.1016/s0169-328x(03)00163-3. Brain Res Mol Brain Res. 2003. PMID: 12829323
Neuroprotective effect of L-arginine in a newborn rat model of acute severe asphyxia.
Martínez-Orgado J, Fernández-Frutos B, González R, Fernández-López D, Urigüen L, Romero E, Moro M, Bonet B, Viveros MP. Martínez-Orgado J, et al. Biol Neonate. 2005;88(4):291-8. doi: 10.1159/000087626. Epub 2005 Aug 18. Biol Neonate. 2005. PMID: 16113523
Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats.
Fernández-López D, Martínez-Orgado J, Nuñez E, Romero J, Lorenzo P, Moro MA, Lizasoain I. Fernández-López D, et al. Pediatr Res. 2006 Aug;60(2):169-73. doi: 10.1203/01.pdr.0000228839.00122.6c. Pediatr Res. 2006. PMID: 16864698
The cannabinoid agonist WIN55212 reduces brain damage in an in vivo model of hypoxic-ischemic encephalopathy in newborn rats.
Fernández-López D, Pazos MR, Tolón RM, Moro MA, Romero J, Lizasoain I, Martínez-Orgado J. Fernández-López D, et al. Pediatr Res. 2007 Sep;62(3):255-60. doi: 10.1203/PDR.0b013e318123fbb8. Pediatr Res. 2007. PMID: 17622949
The seek of neuroprotection: introducing cannabinoids.
Martínez-Orgado J, Fernández-López D, Lizasoain I, Romero J. Martínez-Orgado J, et al. Recent Pat CNS Drug Discov. 2007 Jun;2(2):131-9. doi: 10.2174/157488907780832724. Recent Pat CNS Drug Discov. 2007. PMID: 18221224 Review.
Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets.
Alvarez FJ, Lafuente H, Rey-Santano MC, Mielgo VE, Gastiasoro E, Rueda M, Pertwee RG, Castillo AI, Romero J, Martínez-Orgado J. Alvarez FJ, et al. Pediatr Res. 2008 Dec;64(6):653-8. doi: 10.1203/PDR.0b013e318186e5dd. Pediatr Res. 2008. PMID: 18679164
The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors.
Castillo A, Tolón MR, Fernández-Ruiz J, Romero J, Martinez-Orgado J. Castillo A, et al. Neurobiol Dis. 2010 Feb;37(2):434-40. doi: 10.1016/j.nbd.2009.10.023. Epub 2009 Nov 6. Neurobiol Dis. 2010. PMID: 19900555
The cannabinoid receptor agonist WIN 55,212-2 reduces the initial cerebral damage after hypoxic-ischemic injury in fetal lambs.
Alonso-Alconada D, Alvarez FJ, Alvarez A, Mielgo VE, Goñi-de-Cerio F, Rey-Santano MC, Caballero A, Martinez-Orgado J, Hilario E. Alonso-Alconada D, et al. Brain Res. 2010 Nov 29;1362:150-9. doi: 10.1016/j.brainres.2010.09.050. Epub 2010 Sep 18. Brain Res. 2010. PMID: 20858469
The cannabinoid WIN55212-2 promotes neural repair after neonatal hypoxia-ischemia.
Fernández-López D, Pradillo JM, García-Yébenes I, Martínez-Orgado JA, Moro MA, Lizasoain I. Fernández-López D, et al. Stroke. 2010 Dec;41(12):2956-64. doi: 10.1161/STROKEAHA.110.599357. Stroke. 2010. PMID: 21115947
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