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Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation.
Marti A, Wirbelauer C, Scheffner M, Krek W. Marti A, et al. Nat Cell Biol. 1999 May;1(1):14-9. doi: 10.1038/8984. Nat Cell Biol. 1999. PMID: 10559858
Its activity must be tightly regulated in a cell-cycle-dependent manner to enable programs of gene expression to be coupled closely with cell-cycle position. ...Disruption of the interaction between E2F-1 and p45SKP2 results in a reduction in ubiquitination of E2F-1 …
Its activity must be tightly regulated in a cell-cycle-dependent manner to enable programs of gene expression to be coupled closely w …
Nuclear localization of procaspase-9 and processing by a caspase-3-like activity in mammary epithelial cells.
Ritter PM, Marti A, Blanc C, Baltzer A, Krajewski S, Reed JC, Jaggi R. Ritter PM, et al. Among authors: marti a. Eur J Cell Biol. 2000 May;79(5):358-64. doi: 10.1078/S0171-9335(04)70040-0. Eur J Cell Biol. 2000. PMID: 10887967
Caspase activation is thought to play a major role for the execution of apoptosis. Inactive caspase-9 zymogen is known to be localized within the mitochondrial intermembrane space where it is involved in monitoring mitochondrial damage-associated cytochrome c release and s …
Caspase activation is thought to play a major role for the execution of apoptosis. Inactive caspase-9 zymogen is known to be localize …
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells.
Sutterlüty H, Chatelain E, Marti A, Wirbelauer C, Senften M, Müller U, Krek W. Sutterlüty H, et al. Among authors: marti a. Nat Cell Biol. 1999 Aug;1(4):207-14. doi: 10.1038/12027. Nat Cell Biol. 1999. PMID: 10559918
Expression of p45SKP2 in quiescent fibroblasts promotes p27Kip1 degradation, allows the generation of cyclin-A-dependent kinase activity and induces S phase. Coexpression of a degradation-resistant p27Kip1 mutant suppresses p45SKP2-induced cyclin-A-kinase act …
Expression of p45SKP2 in quiescent fibroblasts promotes p27Kip1 degradation, allows the generation of cyclin-A-dependent kinase activ …
Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway.
Lisztwan J, Marti A, Sutterlüty H, Gstaiger M, Wirbelauer C, Krek W. Lisztwan J, et al. Among authors: marti a. EMBO J. 1998 Jan 15;17(2):368-83. doi: 10.1093/emboj/17.2.368. EMBO J. 1998. PMID: 9430629 Free PMC article.
CUL-1 also associates with cyclin A and p19(SKP1) in vivo and, with p45(SKP2), they assemble into a large multiprotein complex. In Saccharomyces cerevisiae, a complex of similar molecular composition (an F-box protein, a member of the cullin family and …
CUL-1 also associates with cyclin A and p19(SKP1) in vivo and, with p45(SKP2), they assemble into a large multiprotein complex …
Association of human SCF(SKP2) subunit p19(SKP1) with interphase centrosomes and mitotic spindle poles.
Gstaiger M, Marti A, Krek W. Gstaiger M, et al. Among authors: marti a. Exp Cell Res. 1999 Mar 15;247(2):554-62. doi: 10.1006/excr.1999.4386. Exp Cell Res. 1999. PMID: 10066383
Little is known about the corresponding human homolog, p19(SKP1), except that it is expressed throughout the cell cycle and that it too is a component of an S-phase-regulating SCF-E3 ligase complex. ...These findings suggest that p19(SKP1) is a novel component of th …
Little is known about the corresponding human homolog, p19(SKP1), except that it is expressed throughout the cell cycle and that it too is …
Transcription factor activities and gene expression during mouse mammary gland involution.
Marti A, Lazar H, Ritter P, Jaggi R. Marti A, et al. J Mammary Gland Biol Neoplasia. 1999 Apr;4(2):145-52. doi: 10.1023/a:1018721107061. J Mammary Gland Biol Neoplasia. 1999. PMID: 10426393 Review.
Maintenance of mammary epithelial differentiation and milk production during lactation is a consequence of milk removal and the presence of lactogenic hormones, particularly glucocorticoids, insulin and prolactin. After weaning the fall in lactogenic hormones and milk stas …
Maintenance of mammary epithelial differentiation and milk production during lactation is a consequence of milk removal and the prese …
Milk accumulation triggers apoptosis of mammary epithelial cells.
Marti A, Feng Z, Altermatt HJ, Jaggi R. Marti A, et al. Eur J Cell Biol. 1997 Jun;73(2):158-65. Eur J Cell Biol. 1997. PMID: 9208229
Continuous milk production is a consequence of a complex interplay of lactogenic hormones and it depends on the suckling stimulus during lactation. Involution is associated with a massive engorgement of the gland with milk followed by apoptosis of secretory e …
Continuous milk production is a consequence of a complex interplay of lactogenic hormones and it depends on the suckling stimu …
Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland.
Feng Z, Marti A, Jehn B, Altermatt HJ, Chicaiza G, Jaggi R. Feng Z, et al. Among authors: marti a. J Cell Biol. 1995 Nov;131(4):1095-103. doi: 10.1083/jcb.131.4.1095. J Cell Biol. 1995. PMID: 7490285 Free PMC article.
Milk production during lactation is a consequence of the suckling stimulus and the presence of glucocorticoids, prolactin, and insulin. ...Dexamethasone, a very stable and potent glucocorticoid hormone analogue, inhibited involution and programmed cell death in all …
Milk production during lactation is a consequence of the suckling stimulus and the presence of glucocorticoids, prolactin, and insuli …
In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase.
García-Echeverría C, Pearson MA, Marti A, Meyer T, Mestan J, Zimmermann J, Gao J, Brueggen J, Capraro HG, Cozens R, Evans DB, Fabbro D, Furet P, Porta DG, Liebetanz J, Martiny-Baron G, Ruetz S, Hofmann F. García-Echeverría C, et al. Among authors: marti a. Cancer Cell. 2004 Mar;5(3):231-9. doi: 10.1016/s1535-6108(04)00051-0. Cancer Cell. 2004. PMID: 15050915
As expected for a specific IGF-IR kinase inhibitor, NVP-AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. ...Thus, NVP-AEW541 represents a class of selectiv …
As expected for a specific IGF-IR kinase inhibitor, NVP-AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at …
Polyomavirus middle-T antigen lacking a membrane anchor sequence accumulates in the nucleus.
Messerschmitt A, Disela C, Dilworth S, Marti AG, Ballmer-Hofer K. Messerschmitt A, et al. Among authors: marti ag. J Gen Virol. 1996 Jan;77 ( Pt 1):17-26. doi: 10.1099/0022-1317-77-1-17. J Gen Virol. 1996. PMID: 8558125
A mutant virus encoding a truncated form of middle-T lacking a carboxy-terminal hydrophobic sequence mediating membrane association is not oncogenic. ...This suggests that nuclear localization of truncated middle-T may be a consequence of binding to ph
A mutant virus encoding a truncated form of middle-T lacking a carboxy-terminal hydrophobic sequence mediating membrane
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