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Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Fanning SW, Mayne CG, Dharmarajan V, Carlson KE, Martin TA, Novick SJ, Toy W, Green B, Panchamukhi S, Katzenellenbogen BS, Tajkhorshid E, Griffin PR, Shen Y, Chandarlapaty S, Katzenellenbogen JA, Greene GL. Fanning SW, et al. Among authors: martin ta. Elife. 2016 Feb 2;5:e12792. doi: 10.7554/eLife.12792. Elife. 2016. PMID: 26836308 Free PMC article.
Cyclic Ketoximes as Estrogen Receptor β Selective Agonists.
Granchi C, Lapillo M, Spena CR, Rizzolio F, Tuccinardi T, Martin TA, Carlson KE, Katzenellenbogen JA, Minutolo F. Granchi C, et al. Among authors: martin ta. ChemMedChem. 2016 Aug 19;11(16):1752-61. doi: 10.1002/cmdc.201600140. Epub 2016 May 2. ChemMedChem. 2016. PMID: 27135651 Free PMC article.
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.
Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, Hosfield DJ, Chandarlapaty S, Tajkhorshid E, Nettles KW, Griffin PR, Shen Y, Katzenellenbogen JA, Brown M, Greene GL. Fanning SW, et al. Among authors: martin ta. Elife. 2018 Nov 29;7:e37161. doi: 10.7554/eLife.37161. Elife. 2018. PMID: 30489256 Free PMC article.
Metabolic Engineering: Methodologies and Applications.
Volk MJ, Tran VG, Tan SI, Mishra S, Fatma Z, Boob A, Li H, Xue P, Martin TA, Zhao H. Volk MJ, et al. Among authors: martin ta. Chem Rev. 2023 May 10;123(9):5521-5570. doi: 10.1021/acs.chemrev.2c00403. Epub 2022 Dec 30. Chem Rev. 2023. PMID: 36584306 Review.
497 results