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The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver.
Hruschka N, Kalisz M, Subijana M, Graña-Castro O, Del Cano-Ochoa F, Brunet LP, Chernukhin I, Sagrera A, De Reynies A, Kloesch B, Chin SF, Burgués O, Andreu D, Bermejo B, Cejalvo JM, Sutton J, Caldas C, Ramón-Maiques S, Carroll JS, Prat A, Real FX, Martinelli P. Hruschka N, et al. Among authors: martinelli p. Oncogene. 2020 Aug;39(32):5455-5467. doi: 10.1038/s41388-020-1376-3. Epub 2020 Jun 25. Oncogene. 2020. PMID: 32587399 Free PMC article.
A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer.
Kloesch B, Ionasz V, Paliwal S, Hruschka N, Martinez de Villarreal J, Öllinger R, Mueller S, Dienes HP, Schindl M, Gruber ES, Stift J, Herndler-Brandstetter D, Lomberk GA, Seidler B, Saur D, Rad R, Urrutia RA, Real FX, Martinelli P. Kloesch B, et al. Among authors: martinelli p. Gut. 2022 Apr;71(4):766-777. doi: 10.1136/gutjnl-2020-321397. Epub 2021 Apr 12. Gut. 2022. PMID: 33846140 Free PMC article.
Pancreatic cancer development and progression: remodeling the model.
Real FX, Cibrián-Uhalte E, Martinelli P. Real FX, et al. Among authors: martinelli p. Gastroenterology. 2008 Sep;135(3):724-8. doi: 10.1053/j.gastro.2008.07.033. Epub 2008 Aug 8. Gastroenterology. 2008. PMID: 18692502 Review. No abstract available.
GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer.
Martinelli P, Carrillo-de Santa Pau E, Cox T, Sainz B Jr, Dusetti N, Greenhalf W, Rinaldi L, Costello E, Ghaneh P, Malats N, Büchler M, Pajic M, Biankin AV, Iovanna J, Neoptolemos J, Real FX. Martinelli P, et al. Gut. 2017 Sep;66(9):1665-1676. doi: 10.1136/gutjnl-2015-311256. Epub 2016 Jun 20. Gut. 2017. PMID: 27325420 Free PMC article.
Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas.
Cobo I, Martinelli P, Flández M, Bakiri L, Zhang M, Carrillo-de-Santa-Pau E, Jia J, Sánchez-Arévalo Lobo VJ, Megías D, Felipe I, Del Pozo N, Millán I, Thommesen L, Bruland T, Olson SH, Smith J, Schoonjans K, Bamlet WR, Petersen GM, Malats N, Amundadottir LT, Wagner EF, Real FX. Cobo I, et al. Among authors: martinelli p. Nature. 2018 Feb 22;554(7693):533-537. doi: 10.1038/nature25751. Epub 2018 Feb 14. Nature. 2018. PMID: 29443959 Free PMC article.
Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.
Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C. Hermann PC, et al. Among authors: martinelli p. Gastroenterology. 2014 Nov;147(5):1119-33.e4. doi: 10.1053/j.gastro.2014.08.002. Epub 2014 Aug 12. Gastroenterology. 2014. PMID: 25127677
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression.
Whissell G, Montagni E, Martinelli P, Hernando-Momblona X, Sevillano M, Jung P, Cortina C, Calon A, Abuli A, Castells A, Castellvi-Bel S, Nacht AS, Sancho E, Stephan-Otto Attolini C, Vicent GP, Real FX, Batlle E. Whissell G, et al. Among authors: martinelli p. Nat Cell Biol. 2014 Jul;16(7):695-707. doi: 10.1038/ncb2992. Epub 2014 Jun 22. Nat Cell Biol. 2014. PMID: 24952462 Free article.
569 results