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An efficient protocol for the solid-phase synthesis of malondiamides.
Vögtle MM, Marzinzik AL. Vögtle MM, et al. Molecules. 2005 Dec 31;10(12):1438-45. doi: 10.3390/10121438. Molecules. 2005. PMID: 18007540 Free PMC article.
Library design for fragment based screening.
Schuffenhauer A, Ruedisser S, Marzinzik AL, Jahnke W, Blommers M, Selzer P, Jacoby E. Schuffenhauer A, et al. Curr Top Med Chem. 2005;5(8):751-62. doi: 10.2174/1568026054637700. Curr Top Med Chem. 2005. PMID: 16101415 Review.
The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: a proof-of-concept study.
Chapelat J, Berst F, Marzinzik AL, Moebitz H, Drueckes P, Trappe J, Fabbro D, Seebach D. Chapelat J, et al. Among authors: marzinzik al. Eur J Med Chem. 2012 Nov;57:1-9. doi: 10.1016/j.ejmech.2012.08.038. Epub 2012 Sep 4. Eur J Med Chem. 2012. PMID: 23041456
Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding.
Marzinzik AL, Amstutz R, Bold G, Bourgier E, Cotesta S, Glickman JF, Götte M, Henry C, Lehmann S, Hartwieg JC, Ofner S, Pellé X, Roddy TP, Rondeau JM, Stauffer F, Stout SJ, Widmer A, Zimmermann J, Zoller T, Jahnke W. Marzinzik AL, et al. ChemMedChem. 2015 Nov;10(11):1884-91. doi: 10.1002/cmdc.201500338. Epub 2015 Sep 18. ChemMedChem. 2015. PMID: 26381451
Recent trends and observations in the design of high-quality screening collections.
Renner S, Popov M, Schuffenhauer A, Roth HJ, Breitenstein W, Marzinzik A, Lewis I, Krastel P, Nigsch F, Jenkins J, Jacoby E. Renner S, et al. Future Med Chem. 2011 Apr;3(6):751-66. doi: 10.4155/fmc.11.15. Future Med Chem. 2011. PMID: 21554080 Review.
Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site.
Fabbro D, Manley PW, Jahnke W, Liebetanz J, Szyttenholm A, Fendrich G, Strauss A, Zhang J, Gray NS, Adrian F, Warmuth M, Pelle X, Grotzfeld R, Berst F, Marzinzik A, Cowan-Jacob SW, Furet P, Mestan J. Fabbro D, et al. Biochim Biophys Acta. 2010 Mar;1804(3):454-62. doi: 10.1016/j.bbapap.2009.12.009. Biochim Biophys Acta. 2010. PMID: 20152788
Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay.
Jahnke W, Grotzfeld RM, Pellé X, Strauss A, Fendrich G, Cowan-Jacob SW, Cotesta S, Fabbro D, Furet P, Mestan J, Marzinzik AL. Jahnke W, et al. J Am Chem Soc. 2010 May 26;132(20):7043-8. doi: 10.1021/ja101837n. J Am Chem Soc. 2010. PMID: 20450175
Towards intracellular delivery of peptides.
Marzinzik AL, Vorherr TE. Marzinzik AL, et al. Chimia (Aarau). 2013;67(12-13):899-904. doi: 10.2533/chimia.2013.899. Chimia (Aarau). 2013. PMID: 24594335
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