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Mass Spectrometry Imaging, Laser Capture Microdissection, and LC-MS/MS of the Same Tissue Section.
Dilillo M, Pellegrini D, Ait-Belkacem R, de Graaf EL, Caleo M, McDonnell LA. Dilillo M, et al. J Proteome Res. 2017 Aug 4;16(8):2993-3001. doi: 10.1021/acs.jproteome.7b00284. Epub 2017 Jul 5. J Proteome Res. 2017. PMID: 28648079
Mass spectrometry imaging (MSI) is able to simultaneously record the distributions of hundreds of molecules directly from tissue. ...The absence of an explicit analyte separation/purification step means MSI lacks the depth of coverage of LC-M
Mass spectrometry imaging (MSI) is able to simultaneously record the distributions of hundreds of molecules directly fr
Enhanced in situ spatial proteomics by effective combination of MALDI imaging and LC-MS/MS.
Schäfer F, Tomar A, Sato S, Teperino R, Imhof A, Lahiri S. Schäfer F, et al. Mol Cell Proteomics. 2024 Jul 10:100811. doi: 10.1016/j.mcpro.2024.100811. Online ahead of print. Mol Cell Proteomics. 2024. PMID: 38996918 Free article.
Here, we present a combination of experimental and computational approaches that allows a more comprehensive investigation of molecular heterogeneity within tissues than by either shotgun LC-MS/MS or MALDI imaging alone. We applied our pipeline …
Here, we present a combination of experimental and computational approaches that allows a more comprehensive investigation of molecular hete …
A Protocol for the Acquisition of Comprehensive Proteomics Data from Single Cases Using Formalin-Fixed Paraffin Embedded Sections.
Acland M, Mittal P, Arentz G, Whitehead F, Hoffmann P, Klingler-Hoffmann M, Oehler MK. Acland M, et al. Methods Protoc. 2022 Jul 10;5(4):57. doi: 10.3390/mps5040057. Methods Protoc. 2022. PMID: 35893583 Free PMC article.
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) generates spatial intensity maps of molecular features, which can be easily correlated with histology. Additionally, liquid chromatography tandem mass spectro
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) generates spatial intensity …