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Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8.
Williams DE, Dalisay DS, Li F, Amphlett J, Maneerat W, Chavez MA, Wang YA, Matainaho T, Yu W, Brown PJ, Arrowsmith CH, Vedadi M, Andersen RJ. Williams DE, et al. Among authors: matainaho t. Org Lett. 2013 Jan 18;15(2):414-7. doi: 10.1021/ol303416k. Epub 2012 Dec 28. Org Lett. 2013. PMID: 23272941
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