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Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2.
Sanders B, Pokhrel S, Labbe A, Mathews I, Cooper C, Davidson R, Phillips G, Weiss K, Zhang Q, O'Neill H, Kaur M, Ferrins L, Schmidt J, Reichard W, Surendranathan S, Parvathareddy J, Phillips L, Rainville C, Sterner D, Kumaran D, Andi B, Babnigg G, Moriarrty N, Adams P, Joachimiak A, Hurst B, Kumar S, Butt T, Jonsson C, Wakatsuki S, Galanie S, Head M, Parks J. Sanders B, et al. Res Sq [Preprint]. 2022 Jul 21:rs.3.rs-906621. doi: 10.21203/rs.3.rs-906621/v1. Res Sq. 2022. PMID: 34642689 Free PMC article. Updated. Preprint.
Protein sequence design with a learned potential.
Anand N, Eguchi R, Mathews II, Perez CP, Derry A, Altman RB, Huang PS. Anand N, et al. Among authors: mathews ii. Nat Commun. 2022 Feb 8;13(1):746. doi: 10.1038/s41467-022-28313-9. Nat Commun. 2022. PMID: 35136054 Free PMC article.
Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.
Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS 2nd, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ. Kariolis MS, et al. Among authors: mathews ii. J Clin Invest. 2017 Jan 3;127(1):183-198. doi: 10.1172/JCI85610. Epub 2016 Nov 28. J Clin Invest. 2017. PMID: 27893463 Free PMC article.
Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution.
Mathews II, Krishna SS, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, Hale J, Hampton E, Han GW, Haugen J, Jaroszewski L, Klock HE, Koesema E, Kreusch A, Kuhn P, Lesley SA, Levin I, Miller MD, Moy K, Nigoghossian E, Paulsen J, Quijano K, Reyes R, Spraggon G, Stevens RC, van den Bedem H, Velasquez J, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Wilson IA. Mathews II, et al. Proteins. 2006 Jun 1;63(4):1106-11. doi: 10.1002/prot.20650. Proteins. 2006. PMID: 16544324 No abstract available.
Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 A resolution.
Mathews II, Krishna SS, Schwarzenbacher R, McMullan D, Jaroszewski L, Miller MD, Abdubek P, Agarwalla S, Ambing E, Axelrod HL, Canaves JM, Carlton D, Chiu HJ, Clayton T, DiDonato M, Duan L, Elsliger MA, Grzechnik SK, Hale J, Hampton E, Haugen J, Jin KK, Klock HE, Koesema E, Kovarik JS, Kreusch A, Kuhn P, Levin I, Morse AT, Nigoghossian E, Okach L, Oommachen S, Paulsen J, Quijano K, Reyes R, Rife CL, Spraggon G, Stevens RC, van den Bedem H, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA. Mathews II, et al. Proteins. 2006 Oct 1;65(1):249-54. doi: 10.1002/prot.21024. Proteins. 2006. PMID: 16865708 No abstract available.
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