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Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane.
Gruss M, Bushell TJ, Bright DP, Lieb WR, Mathie A, Franks NP. Gruss M, et al. Among authors: mathie a. Mol Pharmacol. 2004 Feb;65(2):443-52. doi: 10.1124/mol.65.2.443. Mol Pharmacol. 2004. PMID: 14742687
Neuronal two-pore-domain potassium channels and their regulation by G protein-coupled receptors.
Mathie A. Mathie A. J Physiol. 2007 Jan 15;578(Pt 2):377-85. doi: 10.1113/jphysiol.2006.121582. Epub 2006 Oct 26. J Physiol. 2007. PMID: 17068099 Free PMC article. Review.
The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the alpha(2) adrenergic sedative dexmedetomidine, and cannabinoid agonists.
Linden AM, Aller MI, Leppä E, Vekovischeva O, Aitta-Aho T, Veale EL, Mathie A, Rosenberg P, Wisden W, Korpi ER. Linden AM, et al. Among authors: mathie a. J Pharmacol Exp Ther. 2006 May;317(2):615-26. doi: 10.1124/jpet.105.098525. Epub 2006 Jan 5. J Pharmacol Exp Ther. 2006. PMID: 16397088
TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons.
Brickley SG, Aller MI, Sandu C, Veale EL, Alder FG, Sambi H, Mathie A, Wisden W. Brickley SG, et al. Among authors: mathie a. J Neurosci. 2007 Aug 29;27(35):9329-40. doi: 10.1523/JNEUROSCI.1427-07.2007. J Neurosci. 2007. PMID: 17728447 Free PMC article.
Therapeutic potential of neuronal two-pore domain potassium-channel modulators.
Mathie A, Veale EL. Mathie A, et al. Curr Opin Investig Drugs. 2007 Jul;8(7):555-62. Curr Opin Investig Drugs. 2007. PMID: 17659475 Review.
G(alpha)q-mediated regulation of TASK3 two-pore domain potassium channels: the role of protein kinase C.
Veale EL, Kennard LE, Sutton GL, MacKenzie G, Sandu C, Mathie A. Veale EL, et al. Among authors: mathie a. Mol Pharmacol. 2007 Jun;71(6):1666-75. doi: 10.1124/mol.106.033241. Epub 2007 Mar 20. Mol Pharmacol. 2007. PMID: 17374744
Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability.
Mathie A, Sutton GL, Clarke CE, Veale EL. Mathie A, et al. Pharmacol Ther. 2006 Sep;111(3):567-83. doi: 10.1016/j.pharmthera.2005.11.004. Epub 2006 Jan 10. Pharmacol Ther. 2006. PMID: 16410023 Review.
Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine.
Kennard LE, Chumbley JR, Ranatunga KM, Armstrong SJ, Veale EL, Mathie A. Kennard LE, et al. Among authors: mathie a. Br J Pharmacol. 2005 Mar;144(6):821-9. doi: 10.1038/sj.bjp.0706068. Br J Pharmacol. 2005. PMID: 15685212 Free PMC article.
The two-pore-domain K(+) channels TREK-1 and TASK-3 are differentially modulated by copper and zinc.
Gruss M, Mathie A, Lieb WR, Franks NP. Gruss M, et al. Among authors: mathie a. Mol Pharmacol. 2004 Sep;66(3):530-7. doi: 10.1124/mol.66.3.. Mol Pharmacol. 2004. PMID: 15322244
Selective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zinc.
Clarke CE, Veale EL, Green PJ, Meadows HJ, Mathie A. Clarke CE, et al. Among authors: mathie a. J Physiol. 2004 Oct 1;560(Pt 1):51-62. doi: 10.1113/jphysiol.2004.070292. Epub 2004 Jul 29. J Physiol. 2004. PMID: 15284350 Free PMC article.
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