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Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53.
Mathupala SP, Heese C, Pedersen PL. Mathupala SP, et al. J Biol Chem. 1997 Sep 5;272(36):22776-80. doi: 10.1074/jbc.272.36.22776. J Biol Chem. 1997. PMID: 9278438
We previously reported isolation of the proximal promoter of the Type II hexokinase gene from the highly glycolytic hepatoma AS-30D (Mathupala, S. ...
We previously reported isolation of the proximal promoter of the Type II hexokinase gene from the highly glycolytic hepatoma AS-30D (Math
Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression.
Goel A, Mathupala SP, Pedersen PL. Goel A, et al. Among authors: mathupala sp. J Biol Chem. 2003 Apr 25;278(17):15333-40. doi: 10.1074/jbc.M300608200. Epub 2003 Feb 3. J Biol Chem. 2003. PMID: 12566445
Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention.
Pedersen PL, Mathupala S, Rempel A, Geschwind JF, Ko YH. Pedersen PL, et al. Among authors: mathupala s. Biochim Biophys Acta. 2002 Sep 10;1555(1-3):14-20. doi: 10.1016/s0005-2728(02)00248-7. Biochim Biophys Acta. 2002. PMID: 12206885
Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions.
Mathupala SP, Rempel A, Pedersen PL. Mathupala SP, et al. J Biol Chem. 2001 Nov 16;276(46):43407-12. doi: 10.1074/jbc.M108181200. Epub 2001 Sep 13. J Biol Chem. 2001. PMID: 11557773
Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.
Mathupala SP, Rempel A, Pedersen PL. Mathupala SP, et al. J Bioenerg Biomembr. 1997 Aug;29(4):339-43. doi: 10.1023/a:1022494613613. J Bioenerg Biomembr. 1997. PMID: 9387094 Review.
Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.
Rempel A, Mathupala SP, Griffin CA, Hawkins AL, Pedersen PL. Rempel A, et al. Among authors: mathupala sp. Cancer Res. 1996 Jun 1;56(11):2468-71. Cancer Res. 1996. PMID: 8653677
Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase.
Mathupala SP, Rempel A, Pedersen PL. Mathupala SP, et al. J Biol Chem. 1995 Jul 14;270(28):16918-25. doi: 10.1074/jbc.270.28.16918. J Biol Chem. 1995. PMID: 7622509
Analysis of the sequence enabled the identification of putative promoter elements, including a TATA box, a CAAT element, several Sp-1 sites, and response elements for glucose, insulin, cAMP, Ap-1, and a number of other factors. ...
Analysis of the sequence enabled the identification of putative promoter elements, including a TATA box, a CAAT element, several Sp-1 …
Glucose catabolism in cancer cells: regulation of the Type II hexokinase promoter by glucose and cyclic AMP.
Rempel A, Mathupala SP, Perdersen PL. Rempel A, et al. Among authors: mathupala sp. FEBS Lett. 1996 May 6;385(3):233-7. doi: 10.1016/0014-5793(96)00399-7. FEBS Lett. 1996. PMID: 8647258
In a previous study we isolated and sequenced the hepatoma Type II hexokinase promoter and showed that it is activated by glucose in the highly glycolytic AS-30D hepatoma cell line under study, but not activated in control hepatocytes [Mathupala, S.P., Rempel, A. and Peder …
In a previous study we isolated and sequenced the hepatoma Type II hexokinase promoter and showed that it is activated by glucose in the hig …
Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy.
Mathupala SP, Ko YH, Pedersen PL. Mathupala SP, et al. Semin Cancer Biol. 2009 Feb;19(1):17-24. doi: 10.1016/j.semcancer.2008.11.006. Epub 2008 Dec 3. Semin Cancer Biol. 2009. PMID: 19101634 Free PMC article. Review.
pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma.
Caruso JP, Koch BJ, Benson PD, Varughese E, Monterey MD, Lee AE, Dave AM, Kiousis S, Sloan AE, Mathupala SP. Caruso JP, et al. Among authors: mathupala sp. Neoplasia. 2017 Feb;19(2):121-134. doi: 10.1016/j.neo.2016.12.011. Epub 2017 Jan 13. Neoplasia. 2017. PMID: 28092823 Free PMC article.
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