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Assessing the potential of glucokinase activators in diabetes therapy.
Matschinsky FM. Matschinsky FM. Nat Rev Drug Discov. 2009 May;8(5):399-416. doi: 10.1038/nrd2850. Epub 2009 Apr 17. Nat Rev Drug Discov. 2009. PMID: 19373249 Review.
Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients.
Sarabu R, Bizzarro FT, Corbett WL, Dvorozniak MT, Geng W, Grippo JF, Haynes NE, Hutchings S, Garofalo L, Guertin KR, Hilliard DW, Kabat M, Kester RF, Ka W, Liang Z, Mahaney PE, Marcus L, Matschinsky FM, Moore D, Racha J, Radinov R, Ren Y, Qi L, Pignatello M, Spence CL, Steele T, Tengi J, Grimsby J. Sarabu R, et al. Among authors: matschinsky fm. J Med Chem. 2012 Aug 23;55(16):7021-36. doi: 10.1021/jm3008689. Epub 2012 Aug 1. J Med Chem. 2012. PMID: 22809456
Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.
Fenner D, Odili S, Hong HK, Kobayashi Y, Kohsaka A, Siepka SM, Vitaterna MH, Chen P, Zelent B, Grimsby J, Takahashi JS, Matschinsky FM, Bass J. Fenner D, et al. Among authors: matschinsky fm. J Biol Chem. 2011 Nov 11;286(45):39560-72. doi: 10.1074/jbc.M111.269100. Epub 2011 Sep 15. J Biol Chem. 2011. PMID: 21921030 Free PMC article.
Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects.
Matschinsky FM, Zelent B, Doliba NM, Kaestner KH, Vanderkooi JM, Grimsby J, Berthel SJ, Sarabu R. Matschinsky FM, et al. Handb Exp Pharmacol. 2011;(203):357-401. doi: 10.1007/978-3-642-17214-4_15. Handb Exp Pharmacol. 2011. PMID: 21484579 Review.
Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675).
Haynes NE, Corbett WL, Bizzarro FT, Guertin KR, Hilliard DW, Holland GW, Kester RF, Mahaney PE, Qi L, Spence CL, Tengi J, Dvorozniak MT, Railkar A, Matschinsky FM, Grippo JF, Grimsby J, Sarabu R. Haynes NE, et al. Among authors: matschinsky fm. J Med Chem. 2010 May 13;53(9):3618-25. doi: 10.1021/jm100039a. J Med Chem. 2010. PMID: 20405948
Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY).
Cuesta-Muñoz AL, Tuomi T, Cobo-Vuilleumier N, Koskela H, Odili S, Stride A, Buettger C, Otonkoski T, Froguel P, Grimsby J, Garcia-Gimeno M, Matschinsky FM. Cuesta-Muñoz AL, et al. Among authors: matschinsky fm. Diabetes Care. 2010 Feb;33(2):290-2. doi: 10.2337/dc09-0681. Epub 2009 Nov 10. Diabetes Care. 2010. PMID: 19903754 Free PMC article.
Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.
Pino MF, Kim KA, Shelton KD, Lindner J, Odili S, Li C, Collins HW, Shiota M, Matschinsky FM, Magnuson MA. Pino MF, et al. Among authors: matschinsky fm. J Biol Chem. 2007 May 4;282(18):13906-16. doi: 10.1074/jbc.M610094200. Epub 2007 Mar 12. J Biol Chem. 2007. PMID: 17353190
Allosteric activators of glucokinase: potential role in diabetes therapy.
Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF. Grimsby J, et al. Among authors: matschinsky fm. Science. 2003 Jul 18;301(5631):370-3. doi: 10.1126/science.1084073. Science. 2003. PMID: 12869762
Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.
Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM. Gloyn AL, et al. Among authors: matschinsky fm. J Biol Chem. 2005 Apr 8;280(14):14105-13. doi: 10.1074/jbc.M413146200. Epub 2005 Jan 25. J Biol Chem. 2005. PMID: 15677479
The Central Role of Glucokinase in Glucose Homeostasis: A Perspective 50 Years After Demonstrating the Presence of the Enzyme in Islets of Langerhans.
Matschinsky FM, Wilson DF. Matschinsky FM, et al. Front Physiol. 2019 Mar 6;10:148. doi: 10.3389/fphys.2019.00148. eCollection 2019. Front Physiol. 2019. PMID: 30949058 Free PMC article. Review.
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