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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI. Kuro-o M, et al. Among authors: matsumura y. Nature. 1997 Nov 6;390(6655):45-51. doi: 10.1038/36285. Nature. 1997. PMID: 9363890
Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats.
Aizawa H, Saito Y, Nakamura T, Inoue M, Imanari T, Ohyama Y, Matsumura Y, Masuda H, Oba S, Mise N, Kimura K, Hasegawa A, Kurabayashi M, Kuro-o M, Nabeshima Y, Nagai R. Aizawa H, et al. Among authors: matsumura y. Biochem Biophys Res Commun. 1998 Aug 28;249(3):865-71. doi: 10.1006/bbrc.1998.9246. Biochem Biophys Res Commun. 1998. PMID: 9731228
Klotho protein protects against endothelial dysfunction.
Saito Y, Yamagishi T, Nakamura T, Ohyama Y, Aizawa H, Suga T, Matsumura Y, Masuda H, Kurabayashi M, Kuro-o M, Nabeshima Y, Nagai R. Saito Y, et al. Among authors: matsumura y. Biochem Biophys Res Commun. 1998 Jul 20;248(2):324-9. doi: 10.1006/bbrc.1998.8943. Biochem Biophys Res Commun. 1998. PMID: 9675134
2,416 results