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Activated hepatic stellate cells mediate the differentiation of macrophages.
Chang J, Hisamatsu T, Shimamura K, Yoneno K, Adachi M, Naruse H, Igarashi T, Higuchi H, Matsuoka K, Kitazume MT, Ando S, Kamada N, Kanai T, Hibi T. Chang J, et al. Hepatol Res. 2013 Jun;43(6):658-69. doi: 10.1111/j.1872-034X.2012.01111.x. Epub 2012 Oct 29. Hepatol Res. 2013. PMID: 23107150
Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria.
Kamada N, Hisamatsu T, Okamoto S, Sato T, Matsuoka K, Arai K, Nakai T, Hasegawa A, Inoue N, Watanabe N, Akagawa KS, Hibi T. Kamada N, et al. J Immunol. 2005 Nov 15;175(10):6900-8. doi: 10.4049/jimmunol.175.10.6900. J Immunol. 2005. PMID: 16272349
Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells.
Sujino T, Kanai T, Ono Y, Mikami Y, Hayashi A, Doi T, Matsuoka K, Hisamatsu T, Takaishi H, Ogata H, Yoshimura A, Littman DR, Hibi T. Sujino T, et al. Gastroenterology. 2011 Sep;141(3):1014-23. doi: 10.1053/j.gastro.2011.05.052. Epub 2011 Jun 7. Gastroenterology. 2011. PMID: 21699791
Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn's disease.
Miyoshi J, Yajima T, Okamoto S, Matsuoka K, Inoue N, Hisamatsu T, Shimamura K, Nakazawa A, Kanai T, Ogata H, Iwao Y, Mukai M, Hibi T. Miyoshi J, et al. J Gastroenterol. 2011 Sep;46(9):1056-63. doi: 10.1007/s00535-011-0425-7. Epub 2011 Jul 5. J Gastroenterol. 2011. PMID: 21725903
T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice.
Ono Y, Kanai T, Sujino T, Nemoto Y, Kanai Y, Mikami Y, Hayashi A, Matsumoto A, Takaishi H, Ogata H, Matsuoka K, Hisamatsu T, Watanabe M, Hibi T. Ono Y, et al. Gastroenterology. 2012 Nov;143(5):1288-1297. doi: 10.1053/j.gastro.2012.07.108. Epub 2012 Jul 28. Gastroenterology. 2012. PMID: 22850180
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