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NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models.
Bahn G, Park JS, Yun UJ, Lee YJ, Choi Y, Park JS, Baek SH, Choi BY, Cho YS, Kim HK, Han J, Sul JH, Baik SH, Lim J, Wakabayashi N, Bae SH, Han JW, Arumugam TV, Mattson MP, Jo DG. Bahn G, et al. Among authors: mattson mp. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12516-12523. doi: 10.1073/pnas.1819541116. Epub 2019 Jun 4. Proc Natl Acad Sci U S A. 2019. PMID: 31164420 Free PMC article.
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits.
Tang SC, Arumugam TV, Xu X, Cheng A, Mughal MR, Jo DG, Lathia JD, Siler DA, Chigurupati S, Ouyang X, Magnus T, Camandola S, Mattson MP. Tang SC, et al. Among authors: mattson mp. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13798-803. doi: 10.1073/pnas.0702553104. Epub 2007 Aug 10. Proc Natl Acad Sci U S A. 2007. PMID: 17693552 Free PMC article.
Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death.
Arumugam TV, Tang SC, Lathia JD, Cheng A, Mughal MR, Chigurupati S, Magnus T, Chan SL, Jo DG, Ouyang X, Fairlie DP, Granger DN, Vortmeyer A, Basta M, Mattson MP. Arumugam TV, et al. Among authors: mattson mp. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14104-9. doi: 10.1073/pnas.0700506104. Epub 2007 Aug 21. Proc Natl Acad Sci U S A. 2007. PMID: 17715065 Free PMC article.
Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.
Jo DG, Arumugam TV, Woo HN, Park JS, Tang SC, Mughal M, Hyun DH, Park JH, Choi YH, Gwon AR, Camandola S, Cheng A, Cai H, Song W, Markesbery WR, Mattson MP. Jo DG, et al. Among authors: mattson mp. Neurobiol Aging. 2010 Jun;31(6):917-25. doi: 10.1016/j.neurobiolaging.2008.07.003. Epub 2008 Aug 8. Neurobiol Aging. 2010. PMID: 18687504 Free PMC article.
Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease.
Gwon AR, Park JS, Arumugam TV, Kwon YK, Chan SL, Kim SH, Baik SH, Yang S, Yun YK, Choi Y, Kim S, Tang SC, Hyun DH, Cheng A, Dann CE 3rd, Bernier M, Lee J, Markesbery WR, Mattson MP, Jo DG. Gwon AR, et al. Among authors: mattson mp. Aging Cell. 2012 Aug;11(4):559-68. doi: 10.1111/j.1474-9726.2012.00817.x. Epub 2012 Apr 9. Aging Cell. 2012. PMID: 22404891 Free PMC article.
Inhibition of notch signalling ameliorates experimental inflammatory arthritis.
Park JS, Kim SH, Kim K, Jin CH, Choi KY, Jang J, Choi Y, Gwon AR, Baik SH, Yun UJ, Chae SY, Lee S, Kang YM, Lee KC, Arumugam TV, Mattson MP, Park JH, Jo DG. Park JS, et al. Among authors: mattson mp. Ann Rheum Dis. 2015 Jan;74(1):267-74. doi: 10.1136/annrheumdis-2013-203467. Epub 2013 Nov 19. Ann Rheum Dis. 2015. PMID: 24255545
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