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Nuclear receptors in the cross-talk of drug metabolism and inflammation.
Gerbal-Chaloin S, Iankova I, Maurel P, Daujat-Chavanieu M. Gerbal-Chaloin S, et al. Drug Metab Rev. 2013 Feb;45(1):122-44. doi: 10.3109/03602532.2012.756011. Drug Metab Rev. 2013. PMID: 23330545 Review.
Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes.
Ayed-Boussema I, Pascussi JM, Maurel P, Bacha H, Hassen W. Ayed-Boussema I, et al. Int J Toxicol. 2012 Jan-Feb;31(1):86-93. doi: 10.1177/1091581811422453. Epub 2011 Oct 12. Int J Toxicol. 2012. PMID: 21994236
Our results showed that AFB1, at noncytotoxic increasing concentrations, caused a significant upregulation of cytochrome P 2B6 (CYP2B6), CYP3A5, and to a lesser extent CYP3A4 and CYP2C9. ...
Our results showed that AFB1, at noncytotoxic increasing concentrations, caused a significant upregulation of cytochrome P 2B6 (CYP2B …
Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3).
Breuker C, Moreau A, Lakhal L, Tamasi V, Parmentier Y, Meyer U, Maurel P, Lumbroso S, Vilarem MJ, Pascussi JM. Breuker C, et al. Endocrinology. 2010 Apr;151(4):1653-61. doi: 10.1210/en.2009-1435. Epub 2010 Feb 25. Endocrinology. 2010. PMID: 20185760
The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.
Pascussi JM, Gerbal-Chaloin S, Duret C, Daujat-Chavanieu M, Vilarem MJ, Maurel P. Pascussi JM, et al. Annu Rev Pharmacol Toxicol. 2008;48:1-32. doi: 10.1146/annurev.pharmtox.47.120505.105349. Annu Rev Pharmacol Toxicol. 2008. PMID: 17608617 Review.
The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.
Ourlin JC, Lasserre F, Pineau T, Fabre JM, Sa-Cunha A, Maurel P, Vilarem MJ, Pascussi JM. Ourlin JC, et al. Mol Endocrinol. 2003 Sep;17(9):1693-703. doi: 10.1210/me.2002-0383. Epub 2003 Jun 12. Mol Endocrinol. 2003. PMID: 12805410
Pathophysiological factors affecting CAR gene expression.
Pascussi JM, Dvorák Z, Gerbal-Chaloin S, Assenat E, Maurel P, Vilarem MJ. Pascussi JM, et al. Drug Metab Rev. 2003 Nov;35(4):255-68. doi: 10.1081/dmr-120026394. Drug Metab Rev. 2003. PMID: 14705859 Review.
Human hepatocyte culture.
Pichard L, Raulet E, Fabre G, Ferrini JB, Ourlin JC, Maurel P. Pichard L, et al. Methods Mol Biol. 2006;320:283-93. doi: 10.1385/1-59259-998-2:283. Methods Mol Biol. 2006. PMID: 16719400
Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.
Duret C, Daujat-Chavanieu M, Pascussi JM, Pichard-Garcia L, Balaguer P, Fabre JM, Vilarem MJ, Maurel P, Gerbal-Chaloin S. Duret C, et al. Mol Pharmacol. 2006 Jul;70(1):329-39. doi: 10.1124/mol.105.022046. Epub 2006 Apr 11. Mol Pharmacol. 2006. PMID: 16608920
Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor.
de Boussac H, Gondeau C, Briolotti P, Duret C, Treindl F, Römer M, Fabre JM, Herrero A, Ramos J, Maurel P, Templin M, Gerbal-Chaloin S, Daujat-Chavanieu M. de Boussac H, et al. Drug Metab Dispos. 2018 Mar;46(3):223-236. doi: 10.1124/dmd.117.078683. Epub 2017 Dec 21. Drug Metab Dispos. 2018. PMID: 29269410
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