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A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984].
Patel P, Young JG, Mautner V, Ashdown D, Bonney S, Pineda RG, Collins SI, Searle PF, Hull D, Peers E, Chester J, Wallace DM, Doherty A, Leung H, Young LS, James ND. Patel P, et al. Among authors: mautner v. Mol Ther. 2009 Jul;17(7):1292-9. doi: 10.1038/mt.2009.80. Epub 2009 Apr 14. Mol Ther. 2009. PMID: 19367257 Free PMC article. Clinical Trial.
Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer.
Palmer DH, Mautner V, Mirza D, Oliff S, Gerritsen W, van der Sijp JR, Hubscher S, Reynolds G, Bonney S, Rajaratnam R, Hull D, Horne M, Ellis J, Mountain A, Hill S, Harris PA, Searle PF, Young LS, James ND, Kerr DJ. Palmer DH, et al. Among authors: mautner v. J Clin Oncol. 2004 May 1;22(9):1546-52. doi: 10.1200/JCO.2004.10.005. Epub 2004 Mar 29. J Clin Oncol. 2004. PMID: 15051757 Clinical Trial.
Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.
Searle PF, Chen MJ, Hu L, Race PR, Lovering AL, Grove JI, Guise C, Jaberipour M, James ND, Mautner V, Young LS, Kerr DJ, Mountain A, White SA, Hyde EI. Searle PF, et al. Among authors: mautner v. Clin Exp Pharmacol Physiol. 2004 Nov;31(11):811-6. doi: 10.1111/j.1440-1681.2004.04085.x. Clin Exp Pharmacol Physiol. 2004. PMID: 15566399 Review.
Combining gene and immunotherapy for prostate cancer.
Young JG, Green NK, Mautner V, Searle PF, Young LS, James ND. Young JG, et al. Among authors: mautner v. Prostate Cancer Prostatic Dis. 2008;11(2):187-93. doi: 10.1038/sj.pcan.4501008. Epub 2007 Aug 28. Prostate Cancer Prostatic Dis. 2008. PMID: 17726452
The nitroreductase/CB1954 enzyme-prodrug system.
Green NK, Kerr DJ, Mautner V, Harris PA, Searle PF. Green NK, et al. Among authors: mautner v. Methods Mol Med. 2004;90:459-77. doi: 10.1385/1-59259-429-8:459. Methods Mol Med. 2004. PMID: 14657579 No abstract available.
398 results