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DNA gyrase: structure and function.
Reece RJ, Maxwell A. Reece RJ, et al. Among authors: maxwell a. Crit Rev Biochem Mol Biol. 1991;26(3-4):335-75. doi: 10.3109/10409239109114072. Crit Rev Biochem Mol Biol. 1991. PMID: 1657531 Review.
Gyrase belongs to a class of enzymes known as topoisomerases that are involved in the control of topological transitions of DNA. ...In addition, much attention has been focused on DNA gyrase as the intracellular target of a number of antibacterial agents as a
Gyrase belongs to a class of enzymes known as topoisomerases that are involved in the control of topological transitions of DNA. ...I …
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
Pitts SL, Liou GF, Mitchenall LA, Burgin AB, Maxwell A, Neuman KC, Osheroff N. Pitts SL, et al. Among authors: maxwell a. Nucleic Acids Res. 2011 Jun;39(11):4808-17. doi: 10.1093/nar/gkr018. Epub 2011 Feb 7. Nucleic Acids Res. 2011. PMID: 21300644 Free PMC article.
Kinetic, mutagenesis and structural studies indicate that the eukaryotic enzymes utilize a novel variant of the canonical two-metal-ion mechanism to promote DNA scission. ...Based on these findings, we propose that topoisomerase IV cleaves DNA using a two-metal-ion …
Kinetic, mutagenesis and structural studies indicate that the eukaryotic enzymes utilize a novel variant of the canonical two-metal-i …
Single-molecule imaging of DNA gyrase activity in living Escherichia coli.
Stracy M, Wollman AJM, Kaja E, Gapinski J, Lee JE, Leek VA, McKie SJ, Mitchenall LA, Maxwell A, Sherratt DJ, Leake MC, Zawadzki P. Stracy M, et al. Among authors: maxwell a. Nucleic Acids Res. 2019 Jan 10;47(1):210-220. doi: 10.1093/nar/gky1143. Nucleic Acids Res. 2019. PMID: 30445553 Free PMC article.
A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase.
Edwards MJ, Flatman RH, Mitchenall LA, Stevenson CE, Le TB, Clarke TA, McKay AR, Fiedler HP, Buttner MJ, Lawson DM, Maxwell A. Edwards MJ, et al. Among authors: maxwell a. Science. 2009 Dec 4;326(5958):1415-8. doi: 10.1126/science.1179123. Science. 2009. PMID: 19965760
We report the crystal structure of the complex formed between the N-terminal domain of the Escherichia coli gyrase A subunit and simocyclinone D8, revealing two binding pockets that separately accommodate the aminocoumarin and polyketide moieties of the antibiotic. ...Bioc …
We report the crystal structure of the complex formed between the N-terminal domain of the Escherichia coli gyrase A subunit and simo …
Quinolone-resistant gyrase mutants demonstrate decreased susceptibility to triclosan.
Webber MA, Buckner MMC, Redgrave LS, Ifill G, Mitchenall LA, Webb C, Iddles R, Maxwell A, Piddock LJV. Webber MA, et al. Among authors: maxwell a. J Antimicrob Chemother. 2017 Oct 1;72(10):2755-2763. doi: 10.1093/jac/dkx201. J Antimicrob Chemother. 2017. PMID: 29091182
OBJECTIVES: Cross-resistance between antibiotics and biocides is a potentially important driver of MDR. A relationship between susceptibility of Salmonella to quinolones and triclosan has been observed. ...For both, there was a correlation between altered sup …
OBJECTIVES: Cross-resistance between antibiotics and biocides is a potentially important driver of MDR. A relationship between …
Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor.
Hegde SS, Vetting MW, Mitchenall LA, Maxwell A, Blanchard JS. Hegde SS, et al. Among authors: maxwell a. Antimicrob Agents Chemother. 2011 Jan;55(1):110-7. doi: 10.1128/AAC.01158-10. Epub 2010 Oct 11. Antimicrob Agents Chemother. 2011. PMID: 20937785 Free PMC article.
EfsQnr inhibited the ATP-dependent supercoiling activity of DNA gyrase with a 50% inhibitory concentration (IC(50)) of 1.2 μM, while no significant inhibition of ATP-independent relaxation activity was observed. EfsQnr was cytotoxic when overexpressed in Escherichia coli, …
EfsQnr inhibited the ATP-dependent supercoiling activity of DNA gyrase with a 50% inhibitory concentration (IC(50)) of 1.2 μM, while …
The phytotoxin albicidin is a novel inhibitor of DNA gyrase.
Hashimi SM, Wall MK, Smith AB, Maxwell A, Birch RG. Hashimi SM, et al. Among authors: maxwell a. Antimicrob Agents Chemother. 2007 Jan;51(1):181-7. doi: 10.1128/AAC.00918-06. Epub 2006 Oct 30. Antimicrob Agents Chemother. 2007. PMID: 17074789 Free PMC article.
Xanthomonas albilineans produces a family of polyketide-peptide compounds called albicidins which are highly potent antibiotics and phytotoxins as a result of their inhibition of prokaryotic DNA replication. ...Within the albicidin biosynthesis region in X. albiline …
Xanthomonas albilineans produces a family of polyketide-peptide compounds called albicidins which are highly potent antibiotics and p …
Quinolone-DNA interaction: sequence-dependent binding to single-stranded DNA reflects the interaction within the gyrase-DNA complex.
Noble CG, Barnard FM, Maxwell A. Noble CG, et al. Among authors: maxwell a. Antimicrob Agents Chemother. 2003 Mar;47(3):854-62. doi: 10.1128/aac.47.3.854-862.2003. Antimicrob Agents Chemother. 2003. PMID: 12604512 Free PMC article.
We have investigated the interaction of quinolones with DNA by a number of methods to establish whether a particular binding mode correlates with quinolone potency. ...Quinolones bound to single-stranded DNA with a higher affinity, and the binding exhibited s …
We have investigated the interaction of quinolones with DNA by a number of methods to establish whether a particular binding m …
Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase.
Chan PF, Germe T, Bax BD, Huang J, Thalji RK, Bacqué E, Checchia A, Chen D, Cui H, Ding X, Ingraham K, McCloskey L, Raha K, Srikannathasan V, Maxwell A, Stavenger RA. Chan PF, et al. Among authors: maxwell a. Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4492-E4500. doi: 10.1073/pnas.1700721114. Epub 2017 May 15. Proc Natl Acad Sci U S A. 2017. PMID: 28507124 Free PMC article.
We have identified a class of antibacterial thiophenes that target DNA gyrase with a unique mechanism of action and have activity against a range of bacterial pathogens, including strains resistant to fluoroquinolones. ...X-ray crystallography of DNA gyrase-D …
We have identified a class of antibacterial thiophenes that target DNA gyrase with a unique mechanism of action and have activ …
Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression.
Le TB, Stevenson CE, Fiedler HP, Maxwell A, Lawson DM, Buttner MJ. Le TB, et al. Among authors: maxwell a. J Mol Biol. 2011 Apr 22;408(1):40-56. doi: 10.1016/j.jmb.2011.02.035. Epub 2011 Feb 24. J Mol Biol. 2011. PMID: 21354180
Simocyclinone D8 (SD8), a potent DNA gyrase inhibitor made by Streptomyces antibioticus, is exported from the producing organism by the SimX efflux pump. ...Through comparisons of the structures, we postulate a derepression mechanism for SimR that invokes rigid-body …
Simocyclinone D8 (SD8), a potent DNA gyrase inhibitor made by Streptomyces antibioticus, is exported from the producing organism by t …
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