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Activation of the HIF pathway in cancer.
Maxwell PH, Pugh CW, Ratcliffe PJ. Maxwell PH, et al. Curr Opin Genet Dev. 2001 Jun;11(3):293-9. doi: 10.1016/s0959-437x(00)00193-3. Curr Opin Genet Dev. 2001. PMID: 11377966 Review.
Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells.
Harten SK, Esteban MA, Shukla D, Ashcroft M, Maxwell PH. Harten SK, et al. Among authors: maxwell ph. Mol Cancer. 2011 Jul 26;10:89. doi: 10.1186/1476-4598-10-89. Mol Cancer. 2011. PMID: 21791076 Free PMC article.
HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore.
Ong SG, Lee WH, Theodorou L, Kodo K, Lim SY, Shukla DH, Briston T, Kiriakidis S, Ashcroft M, Davidson SM, Maxwell PH, Yellon DM, Hausenloy DJ. Ong SG, et al. Among authors: maxwell ph. Cardiovasc Res. 2014 Oct 1;104(1):24-36. doi: 10.1093/cvr/cvu172. Epub 2014 Jul 25. Cardiovasc Res. 2014. PMID: 25063991
Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation.
Ma D, Lim T, Xu J, Tang H, Wan Y, Zhao H, Hossain M, Maxwell PH, Maze M. Ma D, et al. Among authors: maxwell ph. J Am Soc Nephrol. 2009 Apr;20(4):713-20. doi: 10.1681/ASN.2008070712. Epub 2009 Jan 14. J Am Soc Nephrol. 2009. PMID: 19144758 Free PMC article.
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.
Bishop T, Gallagher D, Pascual A, Lygate CA, de Bono JP, Nicholls LG, Ortega-Saenz P, Oster H, Wijeyekoon B, Sutherland AI, Grosfeld A, Aragones J, Schneider M, van Geyte K, Teixeira D, Diez-Juan A, Lopez-Barneo J, Channon KM, Maxwell PH, Pugh CW, Davies AM, Carmeliet P, Ratcliffe PJ. Bishop T, et al. Among authors: maxwell ph. Mol Cell Biol. 2008 May;28(10):3386-400. doi: 10.1128/MCB.02041-07. Epub 2008 Mar 10. Mol Cell Biol. 2008. PMID: 18332118 Free PMC article.
The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition.
Barriga EH, Maxwell PH, Reyes AE, Mayor R. Barriga EH, et al. Among authors: maxwell ph. J Cell Biol. 2013 May 27;201(5):759-76. doi: 10.1083/jcb.201212100. J Cell Biol. 2013. PMID: 23712262 Free PMC article.
HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
Willam C, Maxwell PH, Nichols L, Lygate C, Tian YM, Bernhardt W, Wiesener M, Ratcliffe PJ, Eckardt KU, Pugh CW. Willam C, et al. Among authors: maxwell ph. J Mol Cell Cardiol. 2006 Jul;41(1):68-77. doi: 10.1016/j.yjmcc.2006.04.009. J Mol Cell Cardiol. 2006. PMID: 16765982
The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha.
Willam C, Nicholls LG, Ratcliffe PJ, Pugh CW, Maxwell PH. Willam C, et al. Among authors: maxwell ph. Adv Enzyme Regul. 2004;44:75-92. doi: 10.1016/j.advenzreg.2003.11.017. Adv Enzyme Regul. 2004. PMID: 15581484 Review. No abstract available.
Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH. Mole DR, et al. Among authors: maxwell ph. Adv Enzyme Regul. 2002;42:333-47. doi: 10.1016/s0065-2571(01)00037-1. Adv Enzyme Regul. 2002. PMID: 12123724 No abstract available.
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. McNeill LA, et al. Among authors: maxwell ph. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1547-50. doi: 10.1016/s0960-894x(02)00219-6. Bioorg Med Chem Lett. 2002. PMID: 12039559
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