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IkappaB kinases: kinsmen with different crafts.
May MJ, Ghosh S. May MJ, et al. Science. 1999 Apr 9;284(5412):271-3. doi: 10.1126/science.284.5412.271. Science. 1999. PMID: 10232975 No abstract available.
Rel/NF-kappa B and I kappa B proteins: an overview.
May MJ, Ghosh S. May MJ, et al. Semin Cancer Biol. 1997 Apr;8(2):63-73. doi: 10.1006/scbi.1997.0057. Semin Cancer Biol. 1997. PMID: 9299584 Review.
Signal transduction through NF-kappa B.
May MJ, Ghosh S. May MJ, et al. Immunol Today. 1998 Feb;19(2):80-8. doi: 10.1016/s0167-5699(97)01197-3. Immunol Today. 1998. PMID: 9509763 Review. No abstract available.
Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo.
Jimi E, Aoki K, Saito H, D'Acquisto F, May MJ, Nakamura I, Sudo T, Kojima T, Okamoto F, Fukushima H, Okabe K, Ohya K, Ghosh S. Jimi E, et al. Nat Med. 2004 Jun;10(6):617-24. doi: 10.1038/nm1054. Epub 2004 May 23. Nat Med. 2004. PMID: 15156202
Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies.
D'Acquisto F, May MJ, Ghosh S. D'Acquisto F, et al. Mol Interv. 2002 Feb;2(1):22-35. doi: 10.1124/mi.2.1.22. Mol Interv. 2002. PMID: 14993359 Review.
New generations of NF-kappa B-targeting anti-inflammatory agents that are specific, efficacious, and cost-effective may therefore complement or replace current therapies. ...
New generations of NF-kappa B-targeting anti-inflammatory agents that are specific, efficacious, and cost-effective may therefore com …
RelB forms transcriptionally inactive complexes with RelA/p65.
Marienfeld R, May MJ, Berberich I, Serfling E, Ghosh S, Neumann M. Marienfeld R, et al. J Biol Chem. 2003 May 30;278(22):19852-60. doi: 10.1074/jbc.M301945200. Epub 2003 Mar 25. J Biol Chem. 2003. PMID: 12657634
Taken together, our findings demonstrate that sequestration of RelA in transcriptionally inactive RelA.RelB complexes provides a molecular mechanism that may explain the repressive role of RelB on NF-kappaB-dependent gene expression....
Taken together, our findings demonstrate that sequestration of RelA in transcriptionally inactive RelA.RelB complexes provides a molecular m …
Characterization of the Ikappa B-kinase NEMO binding domain.
May MJ, Marienfeld RB, Ghosh S. May MJ, et al. J Biol Chem. 2002 Nov 29;277(48):45992-6000. doi: 10.1074/jbc.M206494200. Epub 2002 Sep 19. J Biol Chem. 2002. PMID: 12244103
Finally, we demonstrate that loss of NEMO-binding by IKKbeta through deletion of the NBD renders it catalytically active and that potential phosphorylation within the IKKbeta NBD may serve as a signal to down-regulate IKK activity. ...
Finally, we demonstrate that loss of NEMO-binding by IKKbeta through deletion of the NBD renders it catalytically active and that potential …
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